大肠杆菌K-12中芳香族氨基酸转运系统的调控
Regulation of aromatic amino acid transport systems in Escherichia coli K-12.
作者信息
Whipp M J, Pittard A J
出版信息
J Bacteriol. 1977 Nov;132(2):453-61. doi: 10.1128/jb.132.2.453-461.1977.
Abstract
The regulation of the aromatic amino acid transport systems was investigated. The common (general) aromatic transport system and the tyrosine-specific transport system were found to be subject to repression control, thus confirming earlier reports. In addition, tryosine- and tryptophan-specific transport were found to be enhanced by growth of cells with phenylalanine. The repression and enhancement of the transport systems was abolished in a strain carrying an amber mutation in the regulator gene tyrR. This indicates that the tyrR gene product, which was previously shown to be involved in regulation of aromatic biosynthetic enzymes, is also involved in the regulation of the aromatic amino acid transport systems.
摘要
对芳香族氨基酸转运系统的调控进行了研究。发现通用（一般）芳香族转运系统和酪氨酸特异性转运系统受到阻遏控制，从而证实了早期的报道。此外，发现用苯丙氨酸培养细胞可增强酪氨酸和色氨酸特异性转运。在调节基因tyrR中携带琥珀突变的菌株中，转运系统的阻遏和增强作用被消除。这表明tyrR基因产物，先前已证明其参与芳香族生物合成酶的调控，也参与芳香族氨基酸转运系统的调控。
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2
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Biochim Biophys Acta. 1963 Aug 6;73:623-37. doi: 10.1016/0006-3002(63)90332-9.
3
Activation of tyrosine analogs in relation to enzyme repression.酪氨酸类似物的激活与酶抑制的关系。
Biochem Biophys Res Commun. 1965 Jul 26;20(3):352-9. doi: 10.1016/0006-291x(65)90372-4.
4
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5
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