Promsopa Chakapan, Suwansri Supakan, Khuntikij Paiwon
Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Department of Pathology Head and Neck Surgery, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
World J Otorhinolaryngol Head Neck Surg. 2020 Mar 23;7(1):23-27. doi: 10.1016/j.wjorl.2020.02.002. eCollection 2021 Jan.
To clarify whether the serum squamous cell carcinoma antigen (SCCA) levels of patients with inverted papilloma (IP) are different from patients with nasal polyps (NP) and rhinitis.
Serum SCCA levels were measured in 30 patients with IP and 30 patients with NP at one day before surgery and seven days after surgery and measured in 28 patients with rhinitis.
Elevated serum SCCA levels (>1.5 ng/ml) were found in 80.0% of patients in the IP group, 6.7% of patients in the NP group and 14.3% of patients in the rhinitis group, which was a significant difference. The medians of serum SCCA levels in the IP, NP and rhinitis groups were 3.9, 0.8 and 1.1 ng/ml, respectively, which was a significant difference. The SCCA level in IP group was not significantly correlated according to Krouse Staging. There was a significant difference in serum SCCA levels between the pre- and postoperative stages in the IP group, at 3.9 and 0.8 ng/ml, respectively, while in the NP group the levels were 0.8 and 1.0 ng/ml, not significantly different. With regard to the IP diagnosis in the IP and NP group based on the SCCA level (>1.5 ng/ml), sensitivity and specificity was 80.0% and 93.3%, respectively.
The serum SCCA level in patients with IP was elevated and then it decreased after surgery. This was different from NP and rhinitis patients who mostly had normal levels, which did not change.
明确内翻性乳头状瘤（IP）患者的血清鳞状细胞癌抗原（SCCA）水平是否与鼻息肉（NP）患者及鼻炎患者不同。
在手术前一天及手术后七天测量30例IP患者和30例NP患者的血清SCCA水平，并测量28例鼻炎患者的血清SCCA水平。
IP组80.0%的患者血清SCCA水平升高（>1.5 ng/ml），NP组为6.7%，鼻炎组为14.3%，差异有统计学意义。IP组、NP组和鼻炎组血清SCCA水平的中位数分别为3.9、0.8和1.1 ng/ml，差异有统计学意义。根据Krouse分期，IP组的SCCA水平无显著相关性。IP组术前和术后血清SCCA水平有显著差异，分别为3.9和0.8 ng/ml，而NP组水平分别为0.8和1.0 ng/ml，无显著差异。基于SCCA水平（>1.5 ng/ml）对IP组和NP组进行IP诊断，敏感性和特异性分别为80.0%和93.3%。
IP患者血清SCCA水平升高，术后下降。这与NP和鼻炎患者大多SCCA水平正常且无变化不同。
