Department of Anesthesiology, Ningbo No.6 Hospital, Ningbo, China.
Department of Cardiovascular Medicine, Southern Medical University Affiliated Fengxian Hospital, Shanghai, China.
Arch Physiol Biochem. 2021 Oct;127(5):468-478. doi: 10.1080/13813455.2021.1874997. Epub 2021 Jan 21.
It is reported that elevated visfatin level is associated with gestational diabetes mellitus (GDM). However, the relationship between visfatin level and GDM remains controversial. The aim of our study was to systematically review available literature linking visfatin to GDM for a comprehensive understanding of the relationship between circulating visfatin level and GDM in human. PubMed, The Cochrane Library and Web of Science were searched for studies published up to July 2020. Standard mean difference with 95% confidence interval was calculated to evaluate the relationship between visfatin level and GDM using the Review Manager 5.3 and Stata 12.0. The evidence indicated that no significant difference was observed in the level of circulating visfatin between the women with GDM and normal glucose tolerance, suggesting circulating visfatin level is not independently related to GDM. Nevertheless, visfatin is involved in the development of GDM in obese women.
据报道，高水平的内脂素与妊娠期糖尿病（GDM）有关。然而，内脂素水平与 GDM 之间的关系仍存在争议。本研究旨在系统地回顾目前有关内脂素与 GDM 关系的文献，以全面了解人循环内脂素水平与 GDM 之间的关系。我们检索了截至 2020 年 7 月发表的 PubMed、The Cochrane Library 和 Web of Science 上的研究。使用 Review Manager 5.3 和 Stata 12.0 计算标准化均数差及其 95%置信区间，以评估内脂素水平与 GDM 之间的关系。研究结果表明，GDM 组和正常糖耐量组妇女的循环内脂素水平无显著差异，提示循环内脂素水平与 GDM 无独立相关性。然而，内脂素参与了肥胖妇女 GDM 的发生发展。
