Department of Food and Nutrition/Institute of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Korea.
School of Pharmacy and Medical Sciences, University of South Australia, General Post Office Box 2471, Adelaide, SA 5001, Australia.
Int J Environ Res Public Health. 2018 Sep 24;15(10):2093. doi: 10.3390/ijerph15102093.
Current research indicates curcumin [diferuloylmethane; a polyphenolic compound isolated from the rhizomes of the dietary spice turmeric ()] exerts a beneficial effect on health which may be partly attributable to its anti-oxidative and anti-inflammatory properties. The aim of this review is to examine potential mechanisms of the actions of curcumin in both animal and human studies. Curcumin modulates relevant molecular target pathways to improve glucose and lipid metabolism, suppress inflammation, stimulate antioxidant enzymes, facilitate insulin signalling and reduce gut permeability. Curcumin also inhibits Aβ and tau accumulation in animal models and enhances mitochondria and synaptic function. In conclusion, in high-dose animal studies and in vitro, curcumin exerts a potential beneficial effect on cardiometabolic disease. However, human studies are relatively unconvincing. More intervention studies should be conducted with the new curcumin formulation with improved oral bioavailability.
目前的研究表明，姜黄素（二芳基甲烷；一种从食用香料姜黄的根茎中分离出来的多酚化合物）对健康有有益的影响，这可能部分归因于其抗氧化和抗炎特性。本综述的目的是检查姜黄素在动物和人体研究中的作用的潜在机制。姜黄素调节相关的分子靶途径，以改善葡萄糖和脂质代谢，抑制炎症，刺激抗氧化酶，促进胰岛素信号传导和减少肠道通透性。姜黄素还抑制动物模型中的 Aβ和 tau 积累，并增强线粒体和突触功能。总之，在高剂量动物研究和体外实验中，姜黄素对代谢性心血管疾病有潜在的有益作用。然而，人体研究的结果并不令人信服。应该用新的姜黄素制剂进行更多的干预研究，以提高口服生物利用度。
