Ismail Nurruzanna, Abdullah Noraidatulakma, Abdul Murad Nor Azian, Jamal Rahman, Sulaiman Siti Aishah
UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia, Jalan Yaa'cob Latiff, Cheras, Kuala Lumpur 56000, Malaysia.
Diagnostics (Basel). 2021 Jan 19;11(1):145. doi: 10.3390/diagnostics11010145.
The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their existence in biological fluids. Type 2 diabetes patients will develop cardiovascular disease (CVD) complications, and CVD remains the top risk factor for mortality. Understanding the lncRNA roles in T2D and CVD conditions will allow the future use of lncRNAs to detect CVD complications before the symptoms appear. This review aimed to discuss the roles of lncRNAs in T2D and CVD conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.
非编码RNA（ncRNAs）的发现开启了一个新的范式，即利用ncRNAs作为生物标志物来检测疾病进展。长链非编码RNA（lncRNA）因其特定的细胞来源及其在生物体液中的存在而备受关注。2型糖尿病患者会出现心血管疾病（CVD）并发症，而CVD仍然是导致死亡的首要危险因素。了解lncRNA在2型糖尿病和CVD中的作用，将有助于未来在症状出现之前利用lncRNAs检测CVD并发症。本综述旨在探讨lncRNAs在2型糖尿病和CVD中的作用及其作为2型糖尿病CVD并发症分子生物标志物的诊断潜力。
