Watanabe Hirotaka, Takahara Mitsuyoshi, Katakami Naoto, Matsuoka Taka-Aki, Shimomura Iichiro
Department of Metabolic Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871 Japan.
Department of Diabetes Care Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871 Japan.
Diabetol Int. 2020 May 26;12(1):80-86. doi: 10.1007/s13340-020-00438-6. eCollection 2021 Jan.
On June 18 2018, Japan experienced the North Osaka Earthquake. The shaking intensity was recorded as level 6 of the Japan Meteorological Agency Seismic Intensity Scale. Despite the severe shaking, damages of lifelines and transportation networks were limited, and they were completely recovered within several days. We investigated whether the glycemic control in patients with diabetes was deteriorated over months after the earthquake.
We retrospectively analyzed diabetic outpatients attending the department of Metabolic Medicine, Osaka University Hospital, close to the epicenter of the earthquake, in 2018 ( = 1940), and those in 2017 ( = 1908) as a control. Whether glycated hemoglobin (HbA1c) levels were elevated after the earthquake, and whether the post-earthquake HbA1c elevation was more prevalent in areas with a higher seismic intensity were investigated using the mixed effects model.
Compared to the same periods in 2017, mean HbA1c levels in 2018 were significantly higher 3-6 months after the earthquake ( < 0.05). The risk of HbA1c ≥ 7.0% was 1.6 (95% confidence interval 1.2-2.2) and 1.7 (1.2-2.4) times higher 3-4 and 5-6 months after the earthquake. Furthermore, the proportion of HbA1c deterioration after the earthquake was higher in areas with a higher seismic intensity ( for trend = 0.025).
Glycemic control was significantly deteriorated over months after the 2018 North Osaka Earthquake despite limited damage of lifelines and transportation networks. The deterioration was more prevalent in areas with a high seismic intensity.
2018年6月18日，日本发生了北大阪地震。地震烈度被记录为日本气象厅地震烈度等级中的6级。尽管震动剧烈，但生命线和交通网络的受损情况有限，并且在几天内就完全恢复了。我们调查了地震发生数月后糖尿病患者的血糖控制情况是否恶化。
我们回顾性分析了2018年（n = 1940）在靠近地震震中的大阪大学医院代谢医学科就诊的糖尿病门诊患者，以及2017年（n = 1908）的患者作为对照。使用混合效应模型研究糖化血红蛋白（HbA1c）水平在地震后是否升高，以及地震后HbA1c升高在地震烈度较高地区是否更普遍。
与2017年同期相比，2018年地震后3至6个月的平均HbA1c水平显著更高（P < 0.05）。地震后3至4个月和5至6个月时，HbA1c≥7.0%的风险分别高出1.6倍（95%置信区间1.2 - 2.2）和1.7倍（1.2 - 2.4）。此外，地震后HbA1c恶化的比例在地震烈度较高地区更高（P趋势 = 0.025）。
尽管2018年北大阪地震对生命线和交通网络的破坏有限，但地震发生数月后血糖控制仍显著恶化。这种恶化在地震烈度高的地区更为普遍。
