Department of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Department of Biochemistry, PGIMER, Chandigarh, India.
Arch Osteoporos. 2021 Jan 21;16(1):17. doi: 10.1007/s11657-020-00868-4.
Osteoporosis is a disease with a high burden of morbidity. For its accurate diagnosis, using indigenous data as reference standards is needed. However, normative data on bone density is lacking in India. Therefore, we aimed to determine the reference range for bone density for the healthy population of north India.
Osteoporosis is a major public health problem around the globe including India, resulting in significant morbidity, mortality, and health care burden. However, the reference values used for its diagnosis are largely based on data from the western population, which may lead to over- or underdiagnosis of osteoporosis in Indians. Our study aimed to determine the reference range for bone mineral density for the healthy population of India.
This is a cross-sectional study of 825 subjects (men 380, women 445) (median age: 41 years, IQR 32-55 years), recruited by a house-to-house survey. The population was stratified into decade-wise groups and biochemical measurements including renal and liver function tests, glycated hemoglobin, serum calcium, 25-hydroxyvitamin D, parathyroid hormone, and bone mineral density were performed in all the subjects. The T-scores for men aged > 50 years and post-menopausal women were calculated based on the data generated from this study in young men and women aged 20-40 years.
According to the BMD manufacturer's data, which is based on the western population, 70% of the Indian men (> 50 years) and 48% of the post-menopausal Indian women had osteopenia while 18% of the men and 25% of the women had osteoporosis. However, according to the re-calculated T-scores from the current study, only 56% and 7.2% of men and 33% and 5% of women had osteopenia and osteoporosis, respectively. An age-related decline in bone mineral density, as seen in the western population, was also seen in both Indian men and women.
We have established a reference database for BMD in healthy Indian adult population, which may have clinical implications for the diagnosis and intervention strategies for the management of osteoporosis.
骨质疏松症是一种发病率高的疾病。为了准确诊断，需要使用本土数据作为参考标准。然而，印度缺乏骨密度的规范数据。因此，我们旨在确定印度北部健康人群的骨密度参考范围。
这是一项横断面研究，共纳入 825 名受试者（男性 380 名，女性 445 名）（中位数年龄：41 岁，IQR 32-55 岁），通过逐户调查进行招募。人群按十年分组，对所有受试者进行生化测量，包括肾功能和肝功能检查、糖化血红蛋白、血清钙、25-羟维生素 D、甲状旁腺激素和骨密度。根据本研究中 20-40 岁年轻男性和女性的数据，计算年龄＞50 岁的男性和绝经后女性的 T 评分。
根据基于西方人群的骨密度制造商数据，70%的印度男性（＞50 岁）和 48%的绝经后印度女性存在骨量减少，而 18%的男性和 25%的女性患有骨质疏松症。然而，根据当前研究重新计算的 T 评分，只有 56%和 7.2%的男性和 33%和 5%的女性分别存在骨量减少和骨质疏松症。与西方人群一样，印度男性和女性的骨密度也呈年龄相关下降。
我们建立了一个健康印度成年人群骨密度的参考数据库，这可能对骨质疏松症的诊断和干预策略具有临床意义。
