Snyder E L, DePalma L, Napychank P
Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Conn.
Vox Sang. 1988;54(1):21-3. doi: 10.1111/j.1423-0410.1988.tb01607.x.
We studied the usefulness of two polyester leukocyte removal depth filters for the preparation of leukocyte-poor platelet concentrate. The Sepacell R500A removed approximately 92% of the white cells and 98% of the platelets from stored concentrate. In contrast, the Travenol 4C2423 polyester depth microaggregate filter removed less than 1% of the platelets but only 14% of the leukocytes. These findings were obtained with stored (5-day-old) random donor platelets as well as with 16-hour-old platelets collected by apheresis. We conclude that neither of these two leukocyte removal depth filters are suitable for the preparation of leukocyte-poor platelet concentrate; the Sepacell because it removes too many platelets and the 4C2423 because it removes too few leukocytes. The efficiency of cell removal by polyester filters is likely related to alteration of the polyester filter element during fiber manufacture.
我们研究了两种用于制备少白细胞血小板浓缩物的聚酯白细胞去除深度过滤器的效用。Sepacell R500A从储存的浓缩物中去除了约92%的白细胞和98%的血小板。相比之下，Travenol 4C2423聚酯深度微聚集体过滤器去除的血小板不到1%，但仅去除了14%的白细胞。这些结果是通过储存（5日龄）的随机供体血小板以及通过单采收集的16小时龄血小板获得的。我们得出结论，这两种白细胞去除深度过滤器均不适用于制备少白细胞血小板浓缩物；Sepacell是因为它去除了过多的血小板，而4C2423是因为它去除的白细胞过少。聚酯过滤器去除细胞的效率可能与纤维制造过程中聚酯滤芯的改变有关。
