Doherty Edel, Hobbins Anna, Whitehurst David G T, O'Neill Ciaran
J.E. Cairnes School of Business and Economics, National University of Ireland, Galway, Ireland.
Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada.
Pharmacoecon Open. 2021 Jun;5(2):237-244. doi: 10.1007/s41669-020-00244-5. Epub 2021 Jan 22.
Generic measures of health-related quality of life (HRQoL) permit comparisons of competing demands for healthcare resources using outcomes that reflect the preferences of tax payers. EQ-5D instruments are the most commonly used generic, preference-based measures of HRQoL. The EQ-5D-5L enables respondents to describe their health state using five dimensions of health, each with five response levels. The standardised protocol for the valuation of EQ-5D-5L health states comprises use of the composite time trade-off valuation technique, supplemented by a discrete choice experiment (DCE).
This paper presents the first exploration on attribute non-attendance (ANA) to the dimensions of the EQ-5D-5L using DCE data collected following the standardised protocol.
This paper uses the equality constrained latent class model and the endogenous attribute attendance model to examine ANA to the dimensions of the EQ-5D-5L.
The results suggest that respondents are less likely to consider the physical dimensions of the EQ-5D-5L (such as self-care and usual activities) when evaluating the health states. The effects of ANA on utility scores depends on the interpretation of the underlying reasons for ANA.
We recommend that future value sets based in whole or in part on DCE data examine the impact of and reasons for non-attendance in national valuation studies.
与健康相关的生活质量(HRQoL)的通用测量方法允许使用反映纳税人偏好的结果来比较对医疗资源的竞争需求。EQ-5D工具是最常用的基于偏好的HRQoL通用测量方法。EQ-5D-5L使受访者能够使用五个健康维度来描述他们的健康状况,每个维度有五个响应级别。EQ-5D-5L健康状态估值的标准化方案包括使用综合时间权衡估值技术,并辅以离散选择实验(DCE)。
本文首次利用按照标准化方案收集的DCE数据,对EQ-5D-5L维度的属性不参与(ANA)进行探索。
本文使用平等约束潜在类别模型和内生属性参与模型来检验EQ-5D-5L维度的ANA。
结果表明,受访者在评估健康状态时不太可能考虑EQ-5D-5L的身体维度(如自我护理和日常活动)。ANA对效用分数的影响取决于对ANA潜在原因的解释。
我们建议,未来全部或部分基于DCE数据的价值集,应在国家估值研究中考察不参与的影响和原因。