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本文引用的文献

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A Mobile Gaming Intervention for Persons on Pre-Exposure Prophylaxis: Protocol for Intervention Development and Randomized Controlled Trial.一项针对暴露前预防人群的移动游戏干预措施：干预开发与随机对照试验方案
JMIR Res Protoc. 2020 Sep 14;9(9):e18640. doi: 10.2196/18640.
2
Creating a Theoretically Grounded Gaming App to Increase Adherence to Pre-Exposure Prophylaxis: Lessons From the Development of the Viral Combat Mobile Phone Game.创建一款基于理论的游戏应用程序以提高暴露前预防的依从性：从《病毒战斗》手机游戏开发中汲取的经验教训。
JMIR Serious Games. 2019 Mar 27;7(1):e11861. doi: 10.2196/11861.
3
A systematic review of adherence to oral pre-exposure prophylaxis for HIV - how can we improve uptake and adherence?系统评价口服暴露前预防 HIV 的依从性——我们如何提高使用率和依从性？
BMC Infect Dis. 2018 Nov 16;18(1):581. doi: 10.1186/s12879-018-3463-4.
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Epic Allies, a Gamified Mobile Phone App to Improve Engagement in Care, Antiretroviral Uptake, and Adherence Among Young Men Who Have Sex With Men and Young Transgender Women Who Have Sex With Men: Protocol for a Randomized Controlled Trial.Epic Allies，一款用于提高男男性行为者和男男性行为的年轻跨性别女性参与护理、抗逆转录病毒药物服用及依从性的游戏化手机应用程序：一项随机对照试验方案
JMIR Res Protoc. 2018 Apr 5;7(4):e94. doi: 10.2196/resprot.8811.
5
Predictors of Over-Reporting HIV Pre-exposure Prophylaxis (PrEP) Adherence Among Young Men Who Have Sex With Men (YMSM) in Self-Reported Versus Biomarker Data.自我报告与生物标志物数据中男男性行为者（MSM）HIV 暴露前预防（PrEP）服药依从性过度报告的预测因素。
AIDS Behav. 2018 Apr;22(4):1174-1183. doi: 10.1007/s10461-017-1958-4.
6
The future of digital games for HIV prevention and care.数字游戏在艾滋病预防和护理方面的未来。
Curr Opin HIV AIDS. 2017 Sep;12(5):501-507. doi: 10.1097/COH.0000000000000399.
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Addressing engagement in technology-based behavioural HIV interventions through paradata metrics.通过元数据指标解决基于技术的行为 HIV 干预措施中的参与问题。
Curr Opin HIV AIDS. 2017 Sep;12(5):442-446. doi: 10.1097/COH.0000000000000396.
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Tenofovir, emtricitabine, and tenofovir diphosphate in dried blood spots for determining recent and cumulative drug exposure.用于测定近期和累积药物暴露的干血斑中的替诺福韦、恩曲他滨和二磷酸替诺福韦
AIDS Res Hum Retroviruses. 2013 Feb;29(2):384-90. doi: 10.1089/AID.2012.0089. Epub 2012 Oct 10.
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Psychiatric disorders and sexual risk among adolescents in mental health treatment.精神健康治疗中的青少年精神障碍和性风险。
J Consult Clin Psychol. 2010 Aug;78(4):590-7. doi: 10.1037/a0019632.
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Predictors of medication adherence in high risk youth of color living with HIV.HIV 感染者中的有色人种高危青少年药物依从性的预测因素。
J Pediatr Psychol. 2010 Jul;35(6):593-601. doi: 10.1093/jpepsy/jsp080. Epub 2009 Sep 15.

移动游戏干预对提高暴露前预防措施依从性的影响。

The Impact of a Mobile Gaming Intervention to Increase Adherence to Pre-exposure Prophylaxis.

机构信息

Residence Training Program, Warren Alpert Medical School, Brown University, 345 Blackstone Boulevard, Providence, RI, 02906, USA.

Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA.

出版信息

AIDS Behav. 2021 Jun;25(6):1884-1889. doi: 10.1007/s10461-020-03118-3. Epub 2021 Jan 22.

DOI:10.1007/s10461-020-03118-3
PMID:33483897
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8085097/
Abstract

Pre-exposure prophylaxis is effective in preventing HIV, but data show that its effectiveness is compromised by suboptimal adherence. This randomized controlled trial (n = 69) tested the impact of an iPhone game, Viral Combat, on PrEP adherence over 24 weeks. Tenofovir-diphosphate in red blood cells was collected as a biological outcome of adherence. At 24-weeks, intervention participants were 3.75 (95% CI: 1.20-11.77; p = 0.02) times as likely to engage in optimal PrEP dosing compared to controls. Viral Combat showed preliminary efficacy in improving PrEP adherence for diverse young men who have sex with men.

摘要

暴露前预防（PrEP）在预防艾滋病毒方面是有效的，但数据显示，其效果因依从性不佳而受到影响。这项随机对照试验（n=69）测试了一款名为“Viral Combat”的 iPhone 游戏对 PrEP 依从性的影响，试验时间为 24 周。收集红细胞中的替诺福韦二磷酸盐作为依从性的生物学结果。在 24 周时，与对照组相比，干预组参与者有 3.75 倍（95%CI：1.20-11.77；p=0.02）的可能性达到最佳 PrEP 剂量。Viral Combat 初步显示出对不同男男性行为者提高 PrEP 依从性的效果。