Şehirli Ahmet Özer, Sayıner Serkan
Department of Pharmacology, Faculty of Dentistry, Near East University, Nicosia, Cyprus.
Department of Biochemistry, Faculty of Veterinary Medicine, Near East University, Nicosia, Cyprus.
Med Hypotheses. 2021 Feb;147:110504. doi: 10.1016/j.mehy.2021.110504. Epub 2021 Jan 19.
Declared as a pandemic by the World Health Organization, COVID-19 causes damage to tissues with the cytokine storm. It even causes death in people who are fond of it. In this case, the role of the immune system is vital. In particular, the cycle of melatonin and 5-methoxytryptophol released from the pineal hormone ensures that immunity continues for 24 h. While 5-MTX is active in sunlight, melatonin secretion increases in the dark at night. 5-MTX, like melatonin, has shown antioxidant and immunomodulatory properties in studies. Therefore, people who are sick and those who are not must strictly comply with the 24-h circadian rhythm during this period. We think that it is crucial in terms of being protected from the disease that we should carry out our activities according to the circadian rhythm.
新冠病毒肺炎被世界卫生组织宣布为大流行病，它会通过细胞因子风暴对组织造成损害。它甚至会导致易感人群死亡。在这种情况下，免疫系统的作用至关重要。特别是，松果体激素释放的褪黑素和5-甲氧基色醇的循环确保免疫力持续24小时。5-甲氧基色胺在阳光下有活性，而褪黑素的分泌在夜间黑暗时增加。在研究中，5-甲氧基色胺与褪黑素一样，具有抗氧化和免疫调节特性。因此，在此期间，患病者和未患病者都必须严格遵守24小时昼夜节律。我们认为，按照昼夜节律开展活动对于预防疾病至关重要。
