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新型冠状病毒(SARS-CoV-2)感染对心血管疾病和心肺损伤的影响。

The effects of novel coronavirus (SARS-CoV-2) infection on cardiovascular diseases and cardiopulmonary injuries.

机构信息

Department of Cardiothoracic Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, Zhejiang 315041, China; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.

Department of Cardiothoracic Surgery, Lihuili Hospital affiliated to Ningbo University, Ningbo, Zhejiang 315041, China.

出版信息

Stem Cell Res. 2021 Mar;51:102168. doi: 10.1016/j.scr.2021.102168. Epub 2021 Jan 12.

Abstract

COVID-19 caused by a novel coronavirus named SARS-CoV-2, can elites severe acute respiratory syndrome, severe lung injury, cardiac injury, and even death and became a worldwide pandemic. SARS-CoV-2 infection may result in cardiac injury via several mechanisms, including the expression of angiotensin-converting enzyme 2 (ACE2) receptor and leading to a cytokine storm, can elicit an exaggerated host immune response. This response contributes to multi-organ dysfunction. As an emerging infectious disease, there are limited data on the effects of this infection on patients with underlying cardiovascular comorbidities. In this review, we summarize the early-stage clinical experiences with COVID-19, with particular focus on patients with cardiovascular diseases and cardiopulmonary injuries, and explores potential available evidence regarding the association between COVID-19, and cardiovascular complications.

摘要

由新型冠状病毒 SARS-CoV-2 引起的 COVID-19,可引起严重急性呼吸系统综合征、严重肺部损伤、心脏损伤,甚至死亡,并成为全球性大流行。SARS-CoV-2 感染可能通过多种机制导致心脏损伤,包括表达血管紧张素转换酶 2(ACE2)受体并导致细胞因子风暴,从而引发过度的宿主免疫反应。这种反应导致多器官功能障碍。作为一种新兴传染病,关于这种感染对伴有心血管合并症的患者的影响的数据有限。在这篇综述中,我们总结了 COVID-19 的早期临床经验,特别关注患有心血管疾病和心肺损伤的患者,并探讨了 COVID-19 与心血管并发症之间关联的潜在可用证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c816/7801189/ba69ac4af3c8/gr1_lrg.jpg

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