State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300020, China.
State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
J Mol Cell Biol. 2021 Jul 6;13(3):161-167. doi: 10.1093/jmcb/mjaa064.
The coronavirus disease 2019 (COVID-19) remains a global public health emergency. Despite being caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), besides the lung, this infectious disease also has severe implications in the cardiovascular system. In this review, we summarize diverse clinical complications of the heart and vascular system, as well as the relevant high mortality, in COVID-19 patients. Systemic inflammation and angiotensin-converting enzyme 2-involved signaling networking in SARS-CoV-2 infection and the cardiovascular system may contribute to the manifestations of cardiovascular diseases. Therefore, integration of clinical observations and experimental findings can promote our understanding of the underlying mechanisms, which would aid in identifying and treating cardiovascular injury in patients with COVID-19 appropriately.
2019 年冠状病毒病（COVID-19）仍然是全球公共卫生紧急事件。尽管由严重急性呼吸系统综合症冠状病毒 2（SARS-CoV-2）引起，但除了肺部之外，这种传染病在心血管系统中也有严重的影响。在这篇综述中，我们总结了 COVID-19 患者心脏和血管系统的多种临床并发症以及相关的高死亡率。系统性炎症和 SARS-CoV-2 感染及心血管系统中涉及的血管紧张素转换酶 2 的信号网络可能导致心血管疾病的表现。因此，将临床观察和实验结果结合起来可以促进我们对潜在机制的理解，从而有助于识别和适当治疗 COVID-19 患者的心血管损伤。
