Yu Xujiang, Liu Xinyi, Yang Kai, Chen Xiaoyuan, Li Wanwan
State Key Lab of Metal Matrix Composites, School of Materials Science and Engineering, Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composite, Shanghai Jiao Tong University, Shanghai 200240, China.
ACS Nano. 2021 Feb 23;15(2):2038-2067. doi: 10.1021/acsnano.0c07899. Epub 2021 Jan 23.
Innovative multifunctional nanomaterials have attracted tremendous interest in current research by facilitating simultaneous cancer imaging and therapy. Among them, antimony (Sb)- and bismuth (Bi)-based nanoparticles are important species with multifunction to boost cancer theranostic efficacy. Despite the rapid development, the extensive previous work treated Sb- and Bi-based nanoparticles as mutually independent species, and therefore a thorough understanding of their relationship in cancer theranostics was lacking. We propose here that the identical chemical nature of Sb and Bi, being semimetals, provides their derived nanoparticles with inherent multifunction for near-infrared laser-driven and/or X-ray-based cancer imaging and therapy as well as some other imparted functions. An overview of recent progress on Sb- and Bi-based nanoparticles for cancer theranostics is provided to highlight the relationship between chemical nature and multifunction. The understanding of Sb- and Bi-based nanoparticles in this way might shed light on the further design of smart multifunctional nanoparticles for cancer theranostics.
创新的多功能纳米材料通过促进同步癌症成像和治疗，在当前研究中引起了极大的关注。其中，锑（Sb）基和铋（Bi）基纳米粒子是具有多种功能以提高癌症诊疗效果的重要种类。尽管发展迅速，但以往大量工作将锑基和铋基纳米粒子视为相互独立的种类，因此缺乏对它们在癌症诊疗中的关系的全面理解。我们在此提出，锑和铋具有相同的化学性质，作为半金属，为其衍生的纳米粒子提供了固有的多功能性，可用于近红外激光驱动和/或基于X射线的癌症成像与治疗以及其他一些赋予的功能。本文综述了锑基和铋基纳米粒子在癌症诊疗方面的最新进展，以突出化学性质与多功能性之间的关系。以这种方式理解锑基和铋基纳米粒子可能会为用于癌症诊疗的智能多功能纳米粒子的进一步设计提供思路。
