Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Chemistry. 2018 Nov 27;24(66):17405-17418. doi: 10.1002/chem.201801588. Epub 2018 Oct 1.
Theranostic nanomaterials (NMs) have gained increasing attention for their simultaneous performance of diagnosis and therapy. Bi-based NMs hold great potential as theranostic platforms based on their X-ray sensitive capability, near-infrared driven semiconductor properties, and distinctive structures, which facilitate the computed tomography (CT) imaging, photoacoustic (PA) imaging, radiation therapy, and phototherapy. The sophisticated design in composition, structure, and surface fabrication of Bi-based NMs can endow these NMs with more modalities in cancer diagnosis and therapy. In this Minireview, we focus on the recent advances in Bi-based theranostic NMs. A series of unique structures and functions as well as the underlying property-activity relationship of Bi-based NMs are showcased to highlight their promising imaging and therapeutic performance. At the end, we propose some challenges for the design and preparation of Bi-based NMs to improve their cancer diagnostic and therapeutic performance.
治疗诊断纳米材料（NMs）因其兼具诊断和治疗性能而受到越来越多的关注。基于其 X 射线敏感能力、近红外驱动半导体性质和独特结构，铋基 NMs 作为治疗诊断平台具有巨大的潜力，这有助于计算机断层扫描（CT）成像、光声（PA）成像、放射治疗和光疗。通过在组成、结构和表面制造方面进行复杂设计，铋基 NMs 可以在癌症诊断和治疗中提供更多的方式。在这篇综述中，我们重点介绍了铋基治疗诊断 NMs 的最新进展。展示了一系列独特的结构和功能以及铋基 NMs 的潜在性质-活性关系，以突出其有前途的成像和治疗性能。最后，我们提出了一些设计和制备铋基 NMs 的挑战，以提高其癌症诊断和治疗性能。
