Wen Ya, Zhu Wang, Zhang Xuejun, Sun Shao-Kai
Department of Medical Imaging, Tianjin Medical University Tianjin 300203 China
Department of Radiographic Center, Wuhan Children's Hospital, Tongji Medical College of Huazhong University of Science and Technology Wuhan 430015 China.
RSC Adv. 2022 May 5;12(22):13645-13652. doi: 10.1039/d2ra00993e.
Tiny BaSO rod-based X-ray imaging is the most frequently-used method for clinical diagnosis of gastrointestinal motility disorders. The BaSO rods usually have a small size to pass through the gastrointestinal tract smoothly, but suffer from unavoidably low sensitivity. Herein, we developed BiS capsules as a high-performance X-ray contrast agent for gastrointestinal motility assessment for the first time. The BiS capsules were synthesized by the encapsulation of commercial BiS powder into commercial gelatin capsules and subsequent coating of ultraviolet-curable resin. The prepared BiS capsules showed excellent biocompatibility and and superior X-ray attenuation ability due to the large atomic number and high K-edge value of Bi. The developed BiS capsules can serve as a small but highly sensitive X-ray contrast agent to quantitatively assess gastrointestinal motility in a vincristine-induced gastrointestinal motility disorder model by X-ray, CT and spectral CT imaging successfully, solving the intrinsic drawbacks of clinically used BaSO.
基于微小硫酸钡棒的X射线成像技术是临床诊断胃肠动力障碍最常用的方法。硫酸钡棒通常尺寸较小，以便顺利通过胃肠道，但不可避免地存在灵敏度较低的问题。在此，我们首次开发了铋硫胶囊作为用于胃肠动力评估的高性能X射线造影剂。铋硫胶囊是通过将市售铋硫粉末封装到市售明胶胶囊中，随后涂覆紫外光固化树脂合成的。所制备的铋硫胶囊表现出优异的生物相容性，并且由于铋的大原子序数和高K边值而具有卓越的X射线衰减能力。所开发的铋硫胶囊可作为一种体积小但灵敏度高的X射线造影剂，通过X射线、CT和光谱CT成像成功地在长春新碱诱导的胃肠动力障碍模型中定量评估胃肠动力，解决了临床使用的硫酸钡的固有缺点。
