伊朗氟喹诺酮耐药菌的流行情况：一项系统评价与荟萃分析

Prevalence of Fluoroquinolone-Resistant Species in Iran: A Systematic Review and Meta-Analysis.

作者信息

Khademi Farzad, Sahebkar Amirhossein

机构信息

Department of Microbiology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran.

Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Int J Microbiol. 2020 Oct 30;2020:8868197. doi: 10.1155/2020/8868197. eCollection 2020.

BACKGROUND

species are one of the main causes of bacterial food poisoning worldwide. Recently, WHO reported that the emergence of fluoroquinolone-resistant species is becoming a public health issue around the world. The aim of the present systematic review and meta-analysis was to evaluate the prevalence of the antimicrobial susceptibility patterns of species, especially fluoroquinolone-resistant strains isolated from human and animal origins in Iran.

METHODS

Using related keywords and without date and language limitations, a comprehensive literature search was conducted in PubMed, Scopus, ISI Web of Knowledge, Google Scholar, and SID to identify relevant studies on the prevalence of the antimicrobial susceptibility patterns of species in Iran.

RESULTS

A total of 34 reports (9 in Persian and 25 in English) were selected based on inclusion and exclusion criteria. Disk diffusion, -test, and agar dilution were common methods used for antimicrobial susceptibility testing. The antibiotic resistance profiles of species against fluoroquinolones were as follows: 53.6%, 41.8%, and 0% to ciprofloxacin for , , and , respectively, 24.3% and 25.1% to enrofloxacin for and , respectively, 59.6% and 49.2% to nalidixic acid for and , respectively, and 87.3% and 64.7% to ofloxacin for and , respectively.

CONCLUSION

Our findings revealed a high prevalence of fluoroquinolone-resistant species in Iran. This calls for the use of more effective antibiotics with low resistance rates including aminoglycosides, chloramphenicol, and imipenem.

背景

[物种名称]是全球细菌性食物中毒的主要原因之一。最近，世界卫生组织报告称，耐氟喹诺酮类[物种名称]的出现正成为全球公共卫生问题。本系统评价和荟萃分析的目的是评估[物种名称]抗菌药物敏感性模式的流行情况，特别是从伊朗人和动物中分离出的耐氟喹诺酮菌株。

方法

使用相关关键词，不受日期和语言限制，在PubMed、Scopus、ISI Web of Knowledge、谷歌学术和SID中进行全面文献检索，以确定关于伊朗[物种名称]抗菌药物敏感性模式流行情况的相关研究。

结果

根据纳入和排除标准，共选择了34篇报告（9篇波斯语和25篇英语）。纸片扩散法、[方法名称]试验和琼脂稀释法是常用的抗菌药物敏感性检测方法。[物种名称]对氟喹诺酮类抗生素的耐药谱如下：[物种1]、[物种2]和[物种3]对环丙沙星的耐药率分别为53.6%、41.8%和0%，[物种1]和[物种2]对恩诺沙星的耐药率分别为24.3%和25.1%，[物种1]和[物种2]对萘啶酸的耐药率分别为59.6%和49.2%，[物种1]和[物种2]对氧氟沙星的耐药率分别为87.3%和64.7%。