纳米孔测序技术在病原微生物检测中的应用
The Applications of Nanopore Sequencing Technology in Pathogenic Microorganism Detection.
作者信息
Zhu Xiaojian, Yan Shanshan, Yuan Fenghua, Wan Shaogui
机构信息
Center for Molecular Pathology, Department of Basic Medicine, Gannan Medical University, Ganzhou 341000, China.
Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education, Gannan Medical University, Ganzhou 341000, China.
出版信息
Can J Infect Dis Med Microbiol. 2020 Dec 31;2020:6675206. doi: 10.1155/2020/6675206. eCollection 2020.
Abstract
Infectious diseases are major threats to human health and lead to a serious public health burden. The emergence of new pathogens and the mutation of known pathogens challenge our ability to diagnose and control infectious diseases. Nanopore sequencing technology exhibited versatile applications in pathogenic microorganism detection due to its flexible data throughput. This review article introduced the applications of nanopore sequencing in clinical microbiology and infectious diseases management, including the monitoring of emerging infectious diseases outbreak, identification of pathogen drug resistance, and disease-related microbial communities characterization.
摘要
传染病是对人类健康的重大威胁，并导致严重的公共卫生负担。新病原体的出现和已知病原体的突变对我们诊断和控制传染病的能力构成挑战。纳米孔测序技术因其灵活的数据通量而在病原微生物检测中展现出广泛的应用。这篇综述文章介绍了纳米孔测序在临床微生物学和传染病管理中的应用，包括对新发传染病暴发的监测、病原体耐药性的鉴定以及与疾病相关的微生物群落特征分析。
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