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生物医学遇见芬顿化学。

Biomedicine Meets Fenton Chemistry.

机构信息

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences, Shanghai 200050, P. R. China.

Center for Nanomedicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.

出版信息

Chem Rev. 2021 Feb 24;121(4):1981-2019. doi: 10.1021/acs.chemrev.0c00977. Epub 2021 Jan 25.

Abstract

Since the first connection between Fenton chemistry and biomedicine, numerous studies have been presented in this field. Comprehensive presentation of the guidance from Fenton chemistry and a summary of its representative applications in cancer therapy would help us understand and promote the further development of this field. This comprehensive review first supplies basic information regarding Fenton chemistry, including Fenton reactions and Fenton-like reactions. Subsequently, the current progress of Fenton chemistry is discussed, with some corresponding representative examples presented. Furthermore, the current strategies for further optimizing the performance of chemodynamic therapy guided by Fenton chemistry are highlighted. Most importantly, future perspectives on the combination of biomedicine with Fenton chemistry or a wider range of catalytic chemistry approaches are presented. We hope that this review will attract positive attention in the chemistry, materials science, and biomedicine fields and further tighten their connections.

摘要

自芬顿化学与生物医学首次联系以来,该领域已经提出了许多研究。全面介绍芬顿化学的指导原则,并对其在癌症治疗中的代表性应用进行总结,将有助于我们理解和促进该领域的进一步发展。本综述首先提供了有关芬顿化学的基本信息,包括芬顿反应和类芬顿反应。随后,讨论了芬顿化学的当前进展,并提出了一些相应的代表性实例。此外,还强调了目前通过芬顿化学指导进一步优化化学动力学治疗性能的策略。最重要的是,提出了将生物医学与芬顿化学或更广泛的催化化学方法相结合的未来展望。我们希望本综述将引起化学、材料科学和生物医学领域的积极关注,并进一步加强它们之间的联系。

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