School of Chemical Engineering and Advanced Materials, The University of Adelaide, Adelaide, South Australia 5005, Australia.
Centre for Orthopaedic and Trauma Research, Adelaide Medical School, Discipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, South Australia 5005, Australia.
ACS Biomater Sci Eng. 2021 Feb 8;7(2):441-450. doi: 10.1021/acsbiomaterials.0c01210. Epub 2021 Jan 25.
There is an increasing demand for low-cost and more efficient titanium (Ti) medical implants that will provide improved osseointegration and at the same time reduce the likelihood of infection. In the past decade, additive manufacturing (AM) using metal selective laser melting (SLM) or three-dimensional (3D) printing techniques has emerged to enable novel implant geometries or properties to overcome such potential challenges. This study presents a new surface engineering approach to create bioinspired multistructured surfaces on SLM-printed Ti alloy (Ti6Al4V) implants by combining SLM technology, electrochemical anodization, and hydrothermal (HT) processes. The resulting implants display unique surfaces with a distinctive dual micro- to nano-topography composed of micron-sized spherical features, fabricated by SLM and vertically aligned nanoscale pillar structures as a result of combining anodization and HT treatment. The fabricated implants enhanced hydroxyapatite-like mineral deposition from simulated body fluid (SBF) compared to control. In addition, normal human osteoblast-like cells (NHBCs) showed strong adhesion to the nano-/microstructures and displayed greater propensity to mineralize compared to control surfaces. This engineering approach and the resulting nature-inspired multiscale-structured surface offers desired features for improving osseointegration and antibacterial performance toward the development of next-generation orthopedic and dental implants.
对于低成本、高效率的钛（Ti）医疗植入物的需求日益增长，这些植入物将提供更好的骨整合效果，同时降低感染的可能性。在过去的十年中，使用金属选择性激光熔化（SLM）或三维（3D）打印技术的增材制造（AM）技术已经出现，能够实现新的植入物几何形状或特性，以克服这些潜在的挑战。本研究提出了一种新的表面工程方法，通过结合 SLM 技术、电化学阳极氧化和水热（HT）工艺，在 SLM 打印的 Ti 合金（Ti6Al4V）植入物上创建仿生多结构表面。所得到的植入物具有独特的表面，具有独特的双微观到纳观形貌，由 SLM 制造的微米级球形特征和由于阳极氧化和 HT 处理而垂直排列的纳米级柱结构组成。与对照相比，制备的植入物增强了模拟体液（SBF）中类羟基磷灰石矿物的沉积。此外，正常的人成骨样细胞（NHBC）对纳米/微结构表现出强烈的粘附性，并且与对照表面相比，表现出更大的矿化倾向。这种工程方法和由此产生的受自然启发的多尺度结构表面为改善骨整合和抗菌性能提供了所需的特征，以开发下一代骨科和牙科植入物。
