Sun Xuetong, Lin Huaishu, Zhang Chunyu, Huang Ruiran, Liu Ying, Zhang Gong, Di Si
Center for Precision Engineering, Guangzhou Institutes of Advanced Technology, Guangzhou 511458, China.
Guangdong Technical College of Water Resources and Electric Engineering, Guangzhou 510925, China.
Materials (Basel). 2022 Nov 5;15(21):7811. doi: 10.3390/ma15217811.
Selective laser melting manufacture of patient specific Ti implants is serving as a promising approach for bone tissue engineering. The success of implantation is governed by effective osseointegration, which depends on the surface properties of implants. To improve the bioactivity and osteogenesis, the universal surface treatment for SLM-Ti implants is to remove the primitive roughness and then reengineer new roughness by various methods. In this study, the micro-sized partially melted Ti particles on the SLM-Ti surface were preserved for assembling mesoporous bioactive glass nanospheres to obtain a unique micro/nano- topography through combination of SLM manufacture and sol-gel processes. The results of simulated body fluid immersion test showed that bioactive ions (Ca, Si) can be continuously and stably released from the MBG nanospheres. The osseointegration properties of SLM-Ti samples, examined using pre-osteoblast cells, showed enhanced adhesion and osteogenic differentiation compared with commercial pure titanium commonly used as orthopedic implants. Overall, the developed approach of construction of the dual micro/nano topography generated on the SLM-Ti native surface could be critical to enhance musculoskeletal implant performance.
选择性激光熔化制造患者特异性钛植入物正成为骨组织工程的一种有前景的方法。植入的成功取决于有效的骨整合，而这又依赖于植入物的表面特性。为了提高生物活性和成骨能力，对选择性激光熔化钛植入物进行的通用表面处理是去除原始粗糙度，然后通过各种方法重新构建新的粗糙度。在本研究中，选择性激光熔化钛表面的微米级部分熔化钛颗粒被保留下来，用于组装介孔生物活性玻璃纳米球，通过选择性激光熔化制造和溶胶 - 凝胶工艺相结合获得独特的微/纳米形貌。模拟体液浸泡试验结果表明，生物活性离子（钙、硅）可以从介孔生物活性玻璃纳米球中持续稳定释放。使用前成骨细胞检测的选择性激光熔化钛样品的骨整合特性表明，与常用作骨科植入物的商业纯钛相比，其黏附性和成骨分化能力增强。总体而言，在选择性激光熔化钛原生表面构建双微/纳米形貌的开发方法对于提高肌肉骨骼植入物性能可能至关重要。
