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基于应激相关替代指标的人体应激的几何方法。

The geometric approach to human stress based on stress-related surrogate measures.

机构信息

Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland.

出版信息

PLoS One. 2021 Jan 25;16(1):e0219414. doi: 10.1371/journal.pone.0219414. eCollection 2021.

Abstract

We present a predictive Geometric Stress Index (pGSI) and its relation to behavioural Entropy ([Formula: see text]). [Formula: see text] is a measure of the complexity of an organism's reactivity to stressors yielding patterns based on different behavioural and physiological variables selected as Surrogate Markers of Stress (SMS). We present a relationship between pGSI and [Formula: see text] in terms of a power law model. This nonlinear relationship describes congruences in complexity derived from analyses of observable and measurable SMS based patterns interpreted as stress. The adjective geometric refers to subdivision(s) of the domain derived from two SMS (heart rate variability and steps frequency) with respect to a positive/negative binary perceptron based on a third SMS (blood oxygenation). The presented power law allows for both quantitative and qualitative evaluations of the consequences of stress measured by pGSI. In particular, we show that elevated stress levels in terms of pGSI leads to a decrease of the [Formula: see text] of the blood oxygenation, measured by peripheral blood oxygenation SpO2 as a model of SMS.

摘要

我们提出了一种预测的几何应激指数(pGSI)及其与行为熵的关系([Formula: see text])。[Formula: see text]是一种衡量生物体对应激源反应复杂性的度量,其基于选择的不同行为和生理变量作为应激替代标记物(SMS)产生模式。我们提出了 pGSI 和[Formula: see text]之间的关系,以幂律模型表示。这种非线性关系描述了源自对可观察和可测量 SMS 模式的分析的复杂性的一致性,这些模式被解释为应激。形容词“几何”是指基于第三个 SMS(血氧)的正/负二值感知器,对源自两个 SMS(心率变异性和步数频率)的域进行细分。所提出的幂律允许对 pGSI 测量的应激的后果进行定量和定性评估。具体来说,我们表明,以 pGSI 衡量的应激水平升高会导致外周血氧 SpO2 作为 SMS 模型的血氧[Formula: see text]降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40cf/7833219/4ba5109ba577/pone.0219414.g001.jpg

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