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爪哇鼷鹿全血的血液学、粘度及呼吸功能

Hematology, viscosity, and respiratory functions of whole blood of the lesser mouse deer, Tragulus javanicus.

作者信息

Snyder G K, Weathers W W

出版信息

J Appl Physiol Respir Environ Exerc Physiol. 1977 May;42(5):673-8. doi: 10.1152/jappl.1977.42.5.673.

DOI:10.1152/jappl.1977.42.5.673
PMID:16863
Abstract

Blood samples from the lesser mouse deer were examined for hematology, viscosity, oxygen dissociation curve, and magnitude of the Bohr effect. Red corpuscle dimensions, determined under oil immersion with an ocular micrometer, averaged 2.2 micron while the cell counts averaged 53 million/micronl blood, and the packed cell volume averaged 31.2%. Blood hemoglobin concentration averaged 11.2 g/100 ml and the calculated mean cell hemoglobin concentration was 38 g/100 ml. The relative viscosity of the mouse deer plasma was 1.97 and increased in a nonlinear manner with hematocrit to 100 at 80% packed cell volume. Oxygen-hemoglobin equilibrium curves, determined with a mixing technique at 37 degrees C and 10, 36 and 71 Torr PCO2, have the same configuration observed in blood from mammals in general. The P50 of the mouse deer blood at pH = 7.40 is 34 Torr and the Bohr effect (deltalog P50/deltapH) is -0.483. The mouse deer have blood hematocrits which are well below the hematocrits observed in mammals with larger erythrocytes, but similar to the blood hematocrits observed in other mammals with small erythrocytes. We suggest that the low hematocrit is an adaptation which circumvents the hemodynamic problems associated with a high blood viscosity and that, in the mouse deer, the expected concomitantly low total blood hemoglobin concentration is compensated by a higher than average mean cell hemoglobin concentration.

摘要

对小鼷鹿的血样进行了血液学、粘度、氧解离曲线和玻尔效应大小的检测。在油浸条件下用目镜测微计测定的红细胞尺寸平均为2.2微米,而细胞计数平均为每微升血液5300万个,血细胞压积平均为31.2%。血液血红蛋白浓度平均为11.2克/100毫升,计算得出的平均细胞血红蛋白浓度为38克/100毫升。小鼷鹿血浆的相对粘度为1.97,随着血细胞比容的增加呈非线性增加,在血细胞压积为80%时达到100。在37℃和10、36和71托二氧化碳分压下用混合技术测定的氧合血红蛋白平衡曲线,其构型与一般哺乳动物血液中观察到的相同。小鼷鹿血液在pH = 7.40时的P50为34托,玻尔效应(deltalog P50/deltapH)为-0.483。小鼷鹿的血细胞压积远低于红细胞较大的哺乳动物所观察到的血细胞压积,但与其他红细胞较小的哺乳动物所观察到的血液血细胞压积相似。我们认为低血细胞压积是一种适应性特征,可避免与高血液粘度相关的血液动力学问题,并且在小鼷鹿中,预期的随之而来的低总血红蛋白浓度通过高于平均水平的平均细胞血红蛋白浓度得到补偿。

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