外膜蛋白进化。
Outer membrane protein evolution.
机构信息
Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Ave., Lawrence KS 66045-3101, United States.
Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Ave., Lawrence KS 66045-3101, United States; Center for Computational Biology, The University of Kansas, 2030 Becker Dr., Lawrence, KS 66045-7534, United States.
出版信息
Curr Opin Struct Biol. 2021 Jun;68:122-128. doi: 10.1016/j.sbi.2021.01.002. Epub 2021 Jan 22.
Abstract
Outer membrane proteins have remarkably homogeneous structure. They are all up down β-barrels. Up down barrels themselves are composed of repeated sets of β-hairpins. The consistency of the usage of the β-hairpin throughout the outer membrane milieu allows for interrogation of the evolution of these repetitive structures. Here we describe recent investigations of outer membrane protein evolution and how evolutionary precepts have been used for novel outer membrane protein design.
摘要
外膜蛋白具有显著的同质性结构。它们都是上下β桶。上下桶本身由重复的β发夹组成。在外膜环境中β发夹的一致性使用允许对这些重复结构的进化进行询问。在这里，我们描述了外膜蛋白进化的最新研究以及进化原理如何用于新型外膜蛋白设计。
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