基于儿茶酚的抗菌聚合物。

Catechol-Based Antimicrobial Polymers.

机构信息

Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.

出版信息

Molecules. 2021 Jan 21;26(3):559. doi: 10.3390/molecules26030559.

Catechol is a key constituent in mussel adhesive proteins and is responsible for strong adhesive property and crosslinking formation. Plant-based polyphenols are also capable of chemical interactions similar to those of catechol and are inherently antimicrobial. This review reports a series of catechol-based antimicrobial polymers classified according to their antimicrobial mechanisms. Catechol is utilized as a surface anchoring group for adhering monomers and polymers of known antimicrobial properties onto various types of surfaces. Additionally, catechol's ability to form strong complexes with metal ions and nanoparticles was utilized to sequester these antimicrobial agents into coatings and polymer matrices. During catechol oxidation, reactive oxygen species (ROS) is generated as a byproduct, and the use of the generated ROS for antimicrobial applications was also introduced. Finally, polymers that utilized the innate antimicrobial property of halogenated catechols and polyphenols were reviewed.

儿茶酚是贻贝黏附蛋白的关键成分，负责其强大的黏附性能和交联形成。植物多酚也具有类似于儿茶酚的化学相互作用，并且具有内在的抗菌性。本综述报告了一系列基于儿茶酚的抗菌聚合物，根据其抗菌机制进行了分类。儿茶酚被用作表面锚固基团，将具有已知抗菌性能的单体和聚合物附着到各种类型的表面上。此外，儿茶酚与金属离子和纳米粒子形成强配合物的能力被用于将这些抗菌剂隔离到涂层和聚合物基质中。在儿茶酚氧化过程中，会产生副产物活性氧（ROS），并介绍了使用生成的 ROS 进行抗菌应用。最后，综述了利用卤代儿茶酚和多酚固有抗菌性的聚合物。