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Mitochondria orchestrate T cell fate and function.

作者信息

Liu Xia, Peng Guangyong

机构信息

Division of Infectious Diseases, Allergy & Immunology and Department of Internal Medicine, Saint Louis University School of Medicine, Saint Louis, MO, USA.

出版信息

Nat Immunol. 2021 Mar;22(3):276-278. doi: 10.1038/s41590-020-00861-6.

DOI:10.1038/s41590-020-00861-6
PMID:33495653
Abstract
摘要

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Mitochondria orchestrate T cell fate and function.线粒体调控T细胞的命运和功能。
Nat Immunol. 2021 Mar;22(3):276-278. doi: 10.1038/s41590-020-00861-6.
2
Mitochondria Dictate Function and Fate of HSCs and T Cells.线粒体决定造血干细胞和 T 细胞的功能和命运。
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Mitochondria and Hypoxia: Metabolic Crosstalk in Cell-Fate Decisions.线粒体与缺氧：细胞命运决策中的代谢串扰
Trends Endocrinol Metab. 2018 Apr;29(4):249-259. doi: 10.1016/j.tem.2018.02.002. Epub 2018 Feb 28.
4
Computational properties of mitochondria in T cell activation and fate.T细胞活化与命运中线粒体的计算特性
Open Biol. 2016 Nov;6(11). doi: 10.1098/rsob.160192.
5
Mitochondrial Networking in T Cell Memory.T 细胞记忆中的线粒体网络。
Cell. 2016 Jun 30;166(1):9-10. doi: 10.1016/j.cell.2016.06.035.
6
Hypoxia Induces Mitochondrial Defect That Promotes T Cell Exhaustion in Tumor Microenvironment Through MYC-Regulated Pathways.缺氧通过 MYC 调控途径诱导肿瘤微环境中的线粒体缺陷促进 T 细胞耗竭。
Front Immunol. 2020 Aug 21;11:1906. doi: 10.3389/fimmu.2020.01906. eCollection 2020.
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Hypoxia and hypoxia-inducible factors as regulators of T cell development, differentiation, and function.缺氧和缺氧诱导因子作为 T 细胞发育、分化和功能的调节剂。
Immunol Res. 2013 Mar;55(1-3):58-70. doi: 10.1007/s12026-012-8349-8.
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CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8 T cell formation.CRISPR 筛选揭示了影响肠道组织驻留记忆 CD8 T 细胞形成的营养依赖性溶酶体和线粒体节点。
Immunity. 2024 Nov 12;57(11):2597-2614.e13. doi: 10.1016/j.immuni.2024.09.013. Epub 2024 Oct 14.
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Regulatory roles of MicroRNA in shaping T cell function, differentiation and polarization.微小RNA在塑造T细胞功能、分化和极化过程中的调控作用。
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Musculoskeletal Progenitor/Stromal Cell-Derived Mitochondria Modulate Cell Differentiation and Therapeutical Function.肌肉骨骼祖细胞/基质细胞衍生的线粒体调节细胞分化和治疗功能。
Front Immunol. 2021 Mar 8;12:606781. doi: 10.3389/fimmu.2021.606781. eCollection 2021.

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SARDH in the 1-C metabolism sculpts the T-cell fate and serves as a potential cancer therapeutic target.1-C代谢中的SARDH塑造T细胞命运并作为潜在的癌症治疗靶点。
Cell Mol Immunol. 2025 Aug 20. doi: 10.1038/s41423-025-01331-5.
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Mitochondrial Metabolism in T-Cell Exhaustion.T细胞耗竭中的线粒体代谢
Int J Mol Sci. 2025 Jul 31;26(15):7400. doi: 10.3390/ijms26157400.
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Bioengineering the metabolic network of CAR T cells with GLP-1 and Urolithin A increases persistence and long-term anti-tumor activity.利用胰高血糖素样肽-1（GLP-1）和尿石素A对嵌合抗原受体T细胞（CAR T细胞）的代谢网络进行生物工程改造，可提高其持久性和长期抗肿瘤活性。

本文引用的文献

1
Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion.低氧持续刺激诱导的线粒体应激会迅速导致 T 细胞耗竭。
Nat Immunol. 2021 Feb;22(2):205-215. doi: 10.1038/s41590-020-00834-9. Epub 2021 Jan 4.
2
Disturbed mitochondrial dynamics in CD8 TILs reinforce T cell exhaustion.CD8 TIL 中受损的线粒体动力学增强了 T 细胞耗竭。
Nat Immunol. 2020 Dec;21(12):1540-1551. doi: 10.1038/s41590-020-0793-3. Epub 2020 Oct 5.
3
Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen.
Cell Rep Med. 2025 Mar 18;6(3):102021. doi: 10.1016/j.xcrm.2025.102021.
4
A Review of Advances in Mitochondrial Research in Cancer.癌症中线粒体研究进展述评。
Cancer Control. 2024 Jan-Dec;31:10732748241299072. doi: 10.1177/10732748241299072.
5
Development of a Competitive Nutrient-Based T-Cell Immunotherapy Designed to Block the Adaptive Warburg Effect in Acute Myeloid Leukemia.一种旨在阻断急性髓系白血病中适应性瓦伯格效应的基于竞争性营养物质的T细胞免疫疗法的开发。
Biomedicines. 2024 Oct 3;12(10):2250. doi: 10.3390/biomedicines12102250.
6
Multifaceted mitochondrial as a novel therapeutic target in dry eye: insights and interventions.多方面的线粒体作为干眼症的新型治疗靶点：见解与干预措施
Cell Death Discov. 2024 Sep 6;10(1):398. doi: 10.1038/s41420-024-02159-0.
7
Peripheral CX3CR1 T cells combined with PD-1 blockade therapy potentiates the anti-tumor efficacy for lung cancer.外周 CX3CR1 T 细胞联合 PD-1 阻断治疗增强了肺癌的抗肿瘤疗效。
Oncoimmunology. 2024 May 22;13(1):2355684. doi: 10.1080/2162402X.2024.2355684. eCollection 2024.
8
Serine synthesis controls mitochondrial biogenesis in macrophages.丝氨酸合成控制巨噬细胞中线粒体生物发生。
Sci Adv. 2024 May 17;10(20):eadn2867. doi: 10.1126/sciadv.adn2867.
9
Cytotoxic response of tumor-infiltrating lymphocytes of head and neck cancer slice cultures under mitochondrial dysfunction.线粒体功能障碍下头颈部癌切片培养物中肿瘤浸润淋巴细胞的细胞毒性反应
Front Oncol. 2024 Mar 7;14:1364577. doi: 10.3389/fonc.2024.1364577. eCollection 2024.
10
Illuminating the immunological landscape: mitochondrial gene defects in pancreatic cancer through a multiomics lens.揭示免疫全景：多组学视角下胰腺癌中线粒体基因缺陷。
Front Immunol. 2024 Mar 6;15:1375143. doi: 10.3389/fimmu.2024.1375143. eCollection 2024.
持续抗原暴露会损害 T 细胞的线粒体氧化磷酸化，从而限制 T 细胞的自我更新。
Nat Immunol. 2020 Sep;21(9):1022-1033. doi: 10.1038/s41590-020-0725-2. Epub 2020 Jul 13.
4
Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy.衰老的 T 细胞在抑制性肿瘤微环境中：肿瘤免疫治疗的新靶点。
J Clin Invest. 2020 Mar 2;130(3):1073-1083. doi: 10.1172/JCI133679.
5
The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8 T Cell Fitness and Functionality.转录因子 Bhlhe40 调控驻留 CD8 T 细胞适应性和功能的线粒体。
Immunity. 2019 Sep 17;51(3):491-507.e7. doi: 10.1016/j.immuni.2019.08.013.
6
PD-1 signaling affects cristae morphology and leads to mitochondrial dysfunction in human CD8 T lymphocytes.PD-1 信号通路影响嵴的形态，导致人 CD8+T 淋巴细胞线粒体功能障碍。
J Immunother Cancer. 2019 Jun 13;7(1):151. doi: 10.1186/s40425-019-0628-7.
7
TLR8-Mediated Metabolic Control of Human Treg Function: A Mechanistic Target for Cancer Immunotherapy.TLR8 介导的人类 Treg 功能代谢控制：癌症免疫治疗的机制靶点。
Cell Metab. 2019 Jan 8;29(1):103-123.e5. doi: 10.1016/j.cmet.2018.09.020. Epub 2018 Oct 18.
8
T Cell Dysfunction in Cancer.肿瘤中的 T 细胞功能障碍。
Cancer Cell. 2018 Apr 9;33(4):547-562. doi: 10.1016/j.ccell.2018.03.012.
9
The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction.肿瘤微环境抑制T细胞线粒体生物合成，以驱动肿瘤内T细胞代谢不足和功能障碍。
Immunity. 2016 Aug 16;45(2):374-88. doi: 10.1016/j.immuni.2016.07.009. Epub 2016 Aug 2.
10
Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion.由抑制性受体PD-1调控的代谢改变导致的生物能量不足是CD8(+) T细胞耗竭的早期驱动因素。
Immunity. 2016 Aug 16;45(2):358-73. doi: 10.1016/j.immuni.2016.07.008. Epub 2016 Aug 2.