一种来自韩国殖民被囊动物的抗菌双环脂肪酸

Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate sp.

机构信息

Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea.

Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Korea.

出版信息

Mar Drugs. 2021 Sep 16;19(9):521. doi: 10.3390/md19090521.

DOI:10.3390/md19090521

PMID:34564183

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8465582/

Abstract

Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amide derivatives (-), and the other two were dicarboxylic derivatives ( and ). The absolute configurations were determined by a bisignate pattern of CD spectroscopy, which revealed that the absolute configurations of amides were opposite to those of dicarboxylates at every stereogenic centers. Compound exhibited the most potent antibacterial activity (MIC, 2 μg/mL).

摘要

从一种韩国殖民被囊动物 sp. 中通过抗菌活性导向分离得到了五个新的双环羧酸。通过 NMR、MS 和 CD 光谱数据的解释阐明了它们的结构。它们都属于 aplidic 酸类。其中三个是酰胺衍生物 (-)，另外两个是二羧酸衍生物 ( 和 )。绝对构型通过 CD 光谱的双信号模式确定，这表明酰胺的绝对构型在每个手性中心都与二羧酸酯相反。化合物表现出最强的抗菌活性（MIC，2 μg/mL）。