Department of Exercise Physiology, Faculty of Sport Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
Department of Exercise Physiology, Faculty of Sport Sciences, University of Birjand, Birjand, Iran.
Br J Clin Pharmacol. 2021 Aug;87(8):3255-3267. doi: 10.1111/bcp.14746. Epub 2021 Feb 21.
We aimed to determine the independent and combined effects of saffron and resistance training on blood pressure (BP) and some chemical biomarkers in the elderly with hypertension.
The present study was a randomized clinical trial on hypertensive men aged 60-70 years who were assigned to a control group (CO) and 3 experimental groups; resistance training (RT); saffron (S); and resistance training + saffron (RTS) for 12 weeks. Dynamic resistance training was applied with moderate intensity. Patients in S and RTS received 1 tablet containing 200 mg of saffron daily. BP variables, chemical biomarkers and anthropometric indicators were measured at weeks 0, 6, 12 and 18. Data were analysed by repeated measurements ANOVA with 95% confidence interval (CI).
In comparison to the CO (153.3 ± 1.18, CI = 10.9-20.2, P < .001) and S (143.3 ± 1.18, CI = 0.97-10.2, P = .01), RTS (137.7 ± 1.18) reduced systolic BP with the effect size partial η of 0.68. Nitric oxide increased in the RTS compared to the CO group (CI = 0.13-0.62, P = .001). There was a significant increase and decrease in adiponectin and endothelin-1 in the S (CI = 0.03-1.20, P = .012; CI = 4.30-17.3, P < .001) and RT (CI = 0.36-1.60, P < .001; CI = 2.26-15.3, P = .003) compared to the CO, respectively. The partial η for nitric oxide, adiponectin and ET-1 were 0.35, 0.35 and 0.38, respectively. There was no significant difference between the groups for atrial natriuretic peptide.
Resistance training and consumption of saffron can improve BP in the elderly with hypertension by affecting the factors involved in altering vascular endothelial resistance. The present study was approved by the Ethics Committee of Iran's sports science research institution (IR.SSRC.REC.1398.020) and registered at the Iranian Registry of Clinical Trials (IRCT20190731044398N1).
本研究旨在确定藏红花和抗阻训练对高血压老年患者血压（BP）和一些生化标志物的独立和联合影响。
本研究为一项随机临床试验，纳入年龄在 60-70 岁的高血压男性，分为对照组（CO）和 3 个实验组：抗阻训练组（RT）、藏红花组（S）和抗阻训练+藏红花组（RTS），干预时间为 12 周。采用中等强度的动态抗阻训练。S 和 RTS 组患者每天服用 1 片含 200mg 藏红花的片剂。在第 0、6、12 和 18 周测量血压变量、生化标志物和人体测量指标。数据采用重复测量方差分析，置信区间为 95%。
与 CO 组（153.3±1.18，CI=10.9-20.2，P<0.001）和 S 组（143.3±1.18，CI=0.97-10.2，P=0.01）相比，RTS 组（137.7±1.18）降低了收缩压，效应量部分 η为 0.68。与 CO 组相比，RTS 组的一氧化氮增加（CI=0.13-0.62，P=0.001）。与 CO 组相比，S 组（CI=0.03-1.20，P=0.012；CI=4.30-17.3，P<0.001）和 RT 组（CI=0.36-1.60，P<0.001；CI=2.26-15.3，P=0.003）中，脂联素和内皮素-1 均显著增加和减少，效应量部分 η分别为 0.35、0.35 和 0.38。各组间心钠肽无显著差异。
抗阻训练和藏红花的摄入可以通过影响改变血管内皮阻力的因素来改善高血压老年患者的血压。本研究经伊朗运动科学研究机构伦理委员会批准（IR.SSRC.REC.1398.020），并在伊朗临床试验注册中心（IRCT20190731044398N1）注册。
