Department of Exercise Physiology, Ferdowsi University of Mashhad, Mashhad, Iran; Department of Exercise Physiology, University of Tehran, Tehran, Iran.
Department of Exercise Physiology, University of Isfahan, Isfahan, Iran.
Physiol Behav. 2021 May 1;233:113352. doi: 10.1016/j.physbeh.2021.113352. Epub 2021 Feb 6.
We aimed to assess the effects of six weeks of resistance training (RT) combined with saffron supplementation on markers implicated in depression as well as happiness levels in untrained young males.
Untrained young male participants were randomly assigned to one of two groups: RT + saffron supplement (RS; n = 14) or RT + placebo (RP; n = 14). For 6 weeks, participants in the RS group took one 150 mg pill of pure saffron immediately after each RT session and at the same time on non-training days. Those assigned to the RP group took a dextrose pill. Concentrations of Anandamide (AEA), 2-Arachidonoylglycerol (2-AG), serotonin, dopamine, β-endorphin (beta-endorphin), tryptophan, happiness levels (via questionnaire), and body composition were assessed before and after the 6 weeks of whole-body supervised RT (4x/week, 3 sets using 60-70% of 1-repetition maximum [1-RM]).
AEA (0.5 ng/ml), 2-AG (0.04 ng/ml), dopamine (0.7 ng/ml), and β-endorphin (9.4 pg/ml) concentrations significantly increased in the RS group (P<0.05) while no changes were detected in the RP group. Serotonin (RS = 1.7 ng/mL and RP = 1 ng/mL) concentrations and happiness levels significantly increased in both groups with greater changes in RS group while tryptophan concentrations remained unchanged (P> 0.05). In addition, both groups significantly increased muscular endurance with greater changes in RS group (P<0.05).
Six weeks of RT combined with saffron supplementation improved AEA, 2-AG, dopamine, β-endorphin, and serotonin concentrations. Moreover, the addition of saffron supplement to chronic RT results in greater improvements in happiness levels than RT alone.
本研究旨在评估六周抗阻训练（RT）联合藏红花补充剂对未经训练的年轻男性抑郁相关标志物及幸福感的影响。
将未经训练的年轻男性参与者随机分为两组：RT+藏红花补充剂组（RS；n=14）或 RT+安慰剂组（RP；n=14）。在 6 周内，RS 组的参与者在每次 RT 训练后和非训练日的同一时间立即服用一片 150mg 的纯藏红花胶囊，而 RP 组的参与者则服用葡萄糖丸。在进行为期 6 周的全身监督 RT（每周 4 次，使用 60-70%的 1 次重复最大重量[1-RM]进行 3 组）前后，评估了 ANANDAMIDE（AEA）、2-ARACHIDONOYLGLYCEROL（2-AG）、血清素、多巴胺、β-内啡肽（beta-endorphin）、色氨酸、幸福感（通过问卷调查）和身体成分。
RS 组的 AEA（0.5ng/ml）、2-AG（0.04ng/ml）、多巴胺（0.7ng/ml）和β-内啡肽（9.4pg/ml）浓度显著增加（P<0.05），而 RP 组则没有变化。两组的血清素（RS=1.7ng/ml 和 RP=1ng/ml）浓度和幸福感水平均显著升高，其中 RS 组的变化更为明显，而色氨酸浓度保持不变（P>0.05）。此外，两组的肌肉耐力均显著提高，RS 组的变化更为明显（P<0.05）。
六周的 RT 联合藏红花补充剂可改善 AEA、2-AG、多巴胺、β-内啡肽和血清素浓度。此外，与单独进行 RT 相比，将藏红花补充剂添加到慢性 RT 中可显著提高幸福感水平。
