Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, Giessen 35392, Germany.
Institute of Food Chemistry and Food Biotechnology, Justus Liebig University Giessen, Heinrich-Buff-Ring 17, Giessen 35392, Germany.
J Agric Food Chem. 2021 Feb 10;69(5):1524-1535. doi: 10.1021/acs.jafc.0c06952. Epub 2021 Jan 26.
Mushrooms are a rich source of dietary fiber. This study aimed to characterize the modulation of colonic microbiota in Zucker rats after supplementing their diet with a biotechnologically produced oyster mushroom (). Microbiota composition and short chain fatty acids (SCFAs) in the colon and bile acids in the plasma of the rats were analyzed to assess the effects of supplementation on the microbiota in the colon and its interplay with the host in the event of hepatic steatosis. Microbiota profiles were distinctly modulated by supplementation between the obese control rats and the obese rats fed the 5% -supplemented diet. enhanced the growth of SCFAs-producing bacterial genera, including , , , and and decreased the relative abundance of the pathogenic genus -. This was also accompanied by distinct changes in the concentrations of bile acids in the plasma and concentrations of SCFAs in the colon, supporting the initial potentiality of as a prebiotic in cases of hepatic steatosis and liver inflammation.
蘑菇是膳食纤维的丰富来源。本研究旨在通过在 Zucker 大鼠的饮食中补充生物技术生产的牡蛎蘑菇（）来表征其对结肠微生物群的调节作用。分析了大鼠结肠中的微生物群落组成和短链脂肪酸（SCFA）以及血浆中的胆汁酸，以评估补充物对结肠中微生物群的影响及其在发生肝脂肪变性时与宿主的相互作用。在肥胖对照组大鼠和肥胖大鼠之间，补充物显著调节了微生物群谱，这些大鼠喂食 5%补充饮食。补充物增强了产 SCFA 的细菌属的生长，包括、、、和，降低了致病菌属-的相对丰度。这也伴随着血浆中胆汁酸浓度和结肠中 SCFA 浓度的明显变化，支持了在肝脂肪变性和肝脏炎症的情况下，作为一种益生元的潜力。
