Department of Biopsychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Bochum, Germany.
Department of Biopsychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Bochum, Germany.
Neurosci Biobehav Rev. 2021 May;124:89-99. doi: 10.1016/j.neubiorev.2021.01.001. Epub 2021 Jan 23.
Psychosocial stress is an omnipresent phenomenon whose neural correlates in humans are still poorly understood. Several paradigms have been developed to induce acute stress in fMRI settings, but it is unclear whether there is a global brain activation pattern related to psychosocial stress. To integrate the different neuronal activation patterns, we conducted an activation likelihood estimation analysis on 31 studies totaling 1279 participants. Studies used the ScanSTRESS, Montreal Imaging Stress Test, aversive viewing paradigm (AVP), Social-Evaluative Threat or Cyberball. The analysis revealed bilateral activation clusters comprising the claustrum, insula and inferior frontal gyrus. This indicates that exposure to psychosocial stress leads to activations in brain areas involved in affective processing and the endocrine stress response. Furthermore, in a systematic review, Cyberball and AVP presented themselves as outliers due to increased activation in motor areas and lack of induction of stress related activity changes, respectively. As different paradigms emphasize different dimensions of psychosocial stress such as social evaluation or performance pressure, future research is needed to identify differences between the paradigms.
心理社会压力是一种普遍存在的现象，其在人类中的神经相关性仍知之甚少。已经开发了几种范式来在 fMRI 环境中诱导急性应激，但尚不清楚是否存在与心理社会应激相关的整体大脑激活模式。为了整合不同的神经元激活模式，我们对 31 项总计 1279 名参与者的研究进行了激活可能性估计分析。研究使用了 ScanSTRESS、蒙特利尔成像应激测试、厌恶观看范式（AVP）、社会评价威胁或 Cyberball。分析显示，双侧激活簇包括屏状核、脑岛和下额回。这表明，暴露于心理社会压力会导致涉及情感处理和内分泌应激反应的大脑区域的激活。此外，在系统评价中，Cyberball 和 AVP 由于在运动区域的激活增加以及缺乏诱导与应激相关的活动变化而表现为异常。由于不同的范式强调心理社会压力的不同方面，例如社会评价或绩效压力，因此需要进一步的研究来确定这些范式之间的差异。
