Department of Education, Psychology and Communication - University of Bari Aldo Moro, Bari, Italy; Section for Neurodiagnostic Applications, Department of Psychiatry and Psychotherapy - Ludwig Maximilians Universität, Munich, Germany; Department of Basic Medical Sciences, Neuroscience and Sense Organs - University of Bari Aldo Moro, Bari, Italy.
Section for Neurodiagnostic Applications, Department of Psychiatry and Psychotherapy - Ludwig Maximilians Universität, Munich, Germany; Department of Psychiatry University of Cologne, Medical Faculty Cologne Germany.
Neurosci Biobehav Rev. 2021 May;124:35-53. doi: 10.1016/j.neubiorev.2021.01.014. Epub 2021 Jan 23.
The thalamus participates in multiple functional brain networks supporting different cognitive abilities. How thalamo-cortical connections map onto the architecture of human cognition remains an outstanding question. The aim of this meta-analysis is to map co-activation between thalamic and extra-thalamic brain regions onto separate cognitive domains and to assess thalamic subdivision specificity within each of the cognitive domains considered. We parsed 93 fMRI studies into twelve cognitive domains. Signed Differential Mapping served to obtain co-activation maps. We then projected the contribution of thalamic subdivisions onto a thalamic atlas to assess cognitive domain specificity. A set of brain regions was flexibly involved with thalamus in several cognitive domains. Thalamic subdivisions showed ample cognitive heterogeneity. Our proposed model represents thalamic involvement in cognition as an "ensemble" of functional subdivisions with common cell properties embedded in separate cortical circuits rather than a homogeneous functional unit.
丘脑参与了支持不同认知能力的多个功能脑网络。丘脑-皮质连接如何映射到人类认知的结构仍然是一个悬而未决的问题。本荟萃分析的目的是将丘脑和丘脑外脑区之间的共激活映射到不同的认知领域，并评估在考虑的每个认知领域中丘脑细分的特异性。我们将 93 项 fMRI 研究分为 12 个认知领域。签名差异映射用于获得共激活图。然后，我们将丘脑细分的贡献投射到丘脑图谱上，以评估认知领域的特异性。一组脑区在几个认知领域与丘脑灵活地相互作用。丘脑细分显示出丰富的认知异质性。我们提出的模型将丘脑在认知中的参与表示为具有共同细胞特性的功能细分的“集合”，这些功能细分嵌入在单独的皮质回路中，而不是同质的功能单元。
