Ha Minji, Park Soo Hwan, Park Inkyung, Kim Taekwan, Lee Jungha, Kim Minah, Kwon Jun Soo
Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Schizophrenia (Heidelb). 2023 Aug 12;9(1):50. doi: 10.1038/s41537-023-00375-8.
Evidence indicating abnormal functional connectivity (FC) among the cortex, thalamus, and cerebellum in schizophrenia patients has increased. However, the role of the thalamus and cerebellum when integrated into intrinsic networks and how those integrated networks interact in schizophrenia patients are largely unknown. We generated an integrative network map by merging thalamic and cerebellar network maps, which were parcellated using a winner-take-all approach, onto a cortical network map. Using cognitive networks, the default mode network (DMN), the dorsal attention network (DAN), the salience network (SAL), and the central executive network (CEN) as regions of interest, the FC of 48 schizophrenia patients was compared with that of 57 healthy controls (HCs). The association between abnormal FC and cognitive impairment was also investigated in patients. FC was lower between the SAL-CEN, SAL-DMN, and DMN-CEN and within-CEN in schizophrenia patients than in HCs. Hypoconnectivity between the DMN-CEN was correlated with impaired cognition in schizophrenia patients. Our findings broadly suggest the plausible role of the thalamus and cerebellum in integrative intrinsic networks in patients, which may contribute to the disrupted triple network and cognitive dysmetria in schizophrenia.
表明精神分裂症患者大脑皮层、丘脑和小脑之间功能连接（FC）异常的证据增多。然而，丘脑和小脑整合到内在网络中的作用以及这些整合网络在精神分裂症患者中如何相互作用，目前仍知之甚少。我们通过将采用赢家通吃方法分割的丘脑和小脑网络图谱合并到皮质网络图谱上，生成了一个整合网络图谱。以认知网络、默认模式网络（DMN）、背侧注意网络（DAN）、突显网络（SAL）和中央执行网络（CEN）作为感兴趣区域，比较了48例精神分裂症患者与57例健康对照（HCs）的FC。还研究了患者中异常FC与认知障碍之间的关联。精神分裂症患者中，SAL-CEN、SAL-DMN和DMN-CEN之间以及CEN内部的FC低于HCs。DMN-CEN之间的低连接性与精神分裂症患者的认知障碍相关。我们的研究结果广泛表明，丘脑和小脑在患者整合内在网络中可能发挥的作用，这可能导致精神分裂症患者三重网络的破坏和认知失调。
