Department of Anesthesiology, Fourth Affiliated Hospital of China Medical University, Shenyang, China.
Department of General Surgery, Fourth Affiliated Hospital of China Medical University, Shenyang, China.
J Int Med Res. 2021 Jan;49(1):300060520985679. doi: 10.1177/0300060520985679.
We investigated the efficacy and safety of sugammadex doses calculated using corrected body weight (CBW) for reversing deep rocuronium-induced neuromuscular blockade (NMB) in morbidly obese patients undergoing laparoscopic bariatric surgery.
One hundred and twenty-five morbidly obese patients were randomly assigned to three groups: (1) a CBW group, n = 50; (2) a total body weight (TBW) group, n = 50; and (3) a control group, n = 25. Deep NMB was maintained using a continuous infusion of rocuronium. At the reappearance of 1 to 2 post-tetanic counts (PTCs), 4 mg/kg sugammadex, calculated using CBW or TBW, were administered.
All the participants in the CBW and TBW groups recovered to a train-of-four (TOF) ratio of 0.9 within 5 minutes. The recovery times from the start of sugammadex administration to a TOF ratio of 0.9 were 2.2 ± 0.7 and 2.0 ± 0.7 minutes in the CBW and TBW groups, respectively. Thus, a sugammadex dose calculated using CBW was not inferior to that calculated using TBW for the reversal of rocuronium-induced deep NMB in morbidly obese patients.
A dose of 4 mg/kg of sugammadex calculated using CBW is efficient and safe for the reversal of deep NMB after a continuous infusion of rocuronium in morbidly obese patients.
ChiCTR1900028652 (Chinese Clinical Trial Registry, www.chictr.org.cn).
我们研究了使用矫正体重（CBW）计算的舒更葡糖钠剂量在腹腔镜减重手术的病态肥胖患者中逆转深度罗库溴铵诱导的神经肌肉阻滞（NMB）的疗效和安全性。
125 名病态肥胖患者被随机分为三组：（1）CBW 组，n=50；（2）总体重（TBW）组，n=50；和（3）对照组，n=25。通过罗库溴铵持续输注维持深度 NMB。在出现 1 到 2 个强直后计数（PTC）时，给予 4mg/kg 舒更葡糖钠，根据 CBW 或 TBW 计算。
CBW 和 TBW 组的所有患者均在 5 分钟内恢复至 4 个成串刺激（TOF）比值 0.9。从舒更葡糖钠给药开始到 TOF 比值为 0.9 的恢复时间分别为 CBW 和 TBW 组的 2.2±0.7 分钟和 2.0±0.7 分钟。因此，使用 CBW 计算的舒更葡糖钠剂量与使用 TBW 计算的剂量一样，在病态肥胖患者中逆转罗库溴铵诱导的深度 NMB 是有效的。
对于病态肥胖患者连续输注罗库溴铵后，使用 CBW 计算的 4mg/kg 舒更葡糖钠剂量是一种有效且安全的深度 NMB 逆转方法。
ChiCTR1900028652（中国临床试验注册中心，www.chictr.org.cn）。
