Medical Research Council Prion Unit at University College London, University College London Institute of Prion Diseases, London, United Kingdom.
Department of Neurodegenerative Disease, University College London Queen Square Institute of Neurology and Division of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London National Health Service Foundation Trust, London, United Kingdom.
J Infect Dis. 2022 Sep 13;226(5):933-937. doi: 10.1093/infdis/jiab033.
Chronic wasting disease (CWD) is the transmissible spongiform encephalopathy or prion disease affecting cervids. In 2016, the first cases of CWD were reported in Europe in Norwegian wild reindeer and moose. The origin and zoonotic potential of these new prion isolates remain unknown. In this study to investigate zoonotic potential we inoculated brain tissue from CWD-infected Norwegian reindeer and moose into transgenic mice overexpressing human prion protein. After prolonged postinoculation survival periods no evidence for prion transmission was seen, suggesting that the zoonotic potential of these isolates is low.
慢性消耗病（CWD）是一种传染性海绵状脑病或朊病毒病，影响鹿科动物。2016 年，欧洲首次在挪威野生驯鹿和驼鹿中报告了 CWD 病例。这些新朊病毒分离株的起源和人畜共患潜力仍然未知。在本研究中，为了调查人畜共患潜力，我们将来自感染 CWD 的挪威驯鹿和驼鹿的脑组织接种到过度表达人朊病毒蛋白的转基因小鼠中。在延长的接种后存活期后，没有发现朊病毒传播的证据，表明这些分离株的人畜共患潜力较低。
