Emerg Infect Dis. 2018 Dec;24(12):2210-2218. doi: 10.3201/eid2412.180702.
Chronic wasting disease (CWD) persists in cervid populations of North America and in 2016 was detected for the first time in Europe in a wild reindeer in Norway. We report the detection of CWD in 3 moose (Alces alces) in Norway, identified through a large scale surveillance program. The cases occurred in 13-14-year-old female moose, and we detected an abnormal form of prion protein (PrP) in the brain but not in lymphoid tissues. Immunohistochemistry revealed that the moose shared the same neuropathologic phenotype, characterized by mostly intraneuronal deposition of PrP. This pattern differed from that observed in reindeer and has not been previously reported in CWD-infected cervids. Moreover, Western blot revealed a PrP type distinguishable from previous CWD cases and from known ruminant prion diseases in Europe, with the possible exception of sheep CH1641. These findings suggest that these cases in moose represent a novel type of CWD.
慢性消耗病（CWD）在北美的鹿种群中持续存在，2016 年在欧洲首次在挪威的野生驯鹿中被发现。我们报告了在挪威的 3 头驼鹿（Alces alces）中检测到 CWD，这是通过大规模监测计划发现的。这些病例发生在 13-14 岁的雌性驼鹿身上，我们在大脑中检测到了异常形式的朊病毒蛋白（PrP），但在淋巴组织中没有检测到。免疫组织化学显示，驼鹿具有相同的神经病理学表型，其特征是 PrP 主要在神经元内沉积。这种模式与在驯鹿中观察到的不同，也没有在以前感染过 CWD 的有蹄类动物中报道过。此外，Western blot 显示出一种与以前的 CWD 病例以及欧洲已知的反刍动物朊病毒病不同的 PrP 类型，可能除了绵羊 CH1641 之外。这些发现表明，这些驼鹿病例代表了一种新型的 CWD。
