Department of Clinical Research, Research and Development Division, Ayurvet Limited, Baddi, Himachal Pradesh, India.
J Med Virol. 2021 Jul;93(7):4576-4584. doi: 10.1002/jmv.26824.
Effective countermeasures against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) demand a better understanding of the pathogen-host interactions. However, such information about the targets, responses, and effects in the host due to the virus is limited, especially so in the case of newly emerged pathogens. The peptide domains that form the interfaces of host and pathogen interacting proteins being evolutionarily conserved, it may be hypothesized that such interactions can be inferred from the similarities in the nucleotide sequences between the host and the pathogen. This communication reports the results of a study based on a parsimonious approach for the identification of the host-virus interactions, where sequence complementarity between the human and SARS-Cov-2 genomes was used to predict several interactions between the host and SARS-CoV-2 at different levels of biological organization. In particular, the findings are suggestive of a direct effect of SARS-CoV-2 on cardiac health. The existing literature on host responses to SARS-CoV-2 and other viruses attest to many of these predicted interactions, supporting the utility of the proposed approach for the identification of host interactions with other novel pathogens.
有效应对严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 需要更好地了解病原体-宿主相互作用。然而，由于病毒的原因，有关宿主中的靶标、反应和影响的此类信息是有限的，对于新出现的病原体尤其如此。形成宿主和病原体相互作用蛋白界面的肽结构域在进化上是保守的，因此可以假设，这些相互作用可以根据宿主和病原体之间的核苷酸序列相似性来推断。本通讯报告了一项研究的结果，该研究基于一种简约的方法来识别宿主-病毒相互作用，该方法利用人类和 SARS-CoV-2 基因组之间的序列互补性来预测宿主和 SARS-CoV-2 之间在不同生物组织水平上的几种相互作用。特别是，研究结果表明 SARS-CoV-2 对心脏健康有直接影响。关于宿主对 SARS-CoV-2 和其他病毒的反应的现有文献证明了其中许多预测的相互作用，支持了该方法用于识别宿主与其他新型病原体相互作用的实用性。
