• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Generation of patient-specific motor neurons in modeling movement diseases.

作者信息

Ding Baojin

机构信息

Department of Biology, University of Louisiana at Lafayette, Lafayette, LA, USA.

出版信息

Neural Regen Res. 2021 Sep;16(9):1799-1800. doi: 10.4103/1673-5374.306083.

DOI:10.4103/1673-5374.306083
PMID:33510083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8328779/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c72/8328779/3cad6b89cef8/NRR-16-1799-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c72/8328779/3cad6b89cef8/NRR-16-1799-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c72/8328779/3cad6b89cef8/NRR-16-1799-g001.jpg

相似文献

1
Generation of patient-specific motor neurons in modeling movement diseases.在运动疾病建模中生成患者特异性运动神经元。
Neural Regen Res. 2021 Sep;16(9):1799-1800. doi: 10.4103/1673-5374.306083.
2
Neural Representation and Causal Models in Motor Cortex.运动皮层中的神经表征与因果模型
J Neurosci. 2017 Mar 22;37(12):3413-3424. doi: 10.1523/JNEUROSCI.1000-16.2017. Epub 2017 Feb 20.
3
Selective Suppression of Local Interneuron Circuits in Human Motor Cortex Contributes to Movement Preparation.选择性抑制人类运动皮层局部中间神经元回路有助于运动准备。
J Neurosci. 2018 Jan 31;38(5):1264-1276. doi: 10.1523/JNEUROSCI.2869-17.2017. Epub 2017 Dec 20.
4
Role of primate basal ganglia and frontal cortex in the internal generation of movements. III. Neuronal activity in the supplementary motor area.灵长类基底神经节和额叶皮质在运动内在产生中的作用。III. 辅助运动区的神经元活动。
Exp Brain Res. 1992;91(3):396-407. doi: 10.1007/BF00227836.
5
Sensorimotor transformations in cortical motor areas.皮质运动区中的感觉运动转换
Neurosci Res. 2003 May;46(1):1-10. doi: 10.1016/s0168-0102(03)00031-2.
6
Generation of motor neurons from pluripotent stem cells.诱导多能干细胞生成运动神经元。
Prog Brain Res. 2012;201:313-31. doi: 10.1016/B978-0-444-59544-7.00015-9.
7
Modeling motor cortical operations by an attractor network of stochastic neurons.通过随机神经元的吸引子网络对运动皮层操作进行建模。
Biol Cybern. 1996 Mar;74(3):255-61. doi: 10.1007/BF00652226.
8
Emerging ideas and tools to study the emergent properties of the cortical neural circuits for voluntary motor control in non-human primates.用于研究非人灵长类动物自主运动控制中皮质神经回路涌现特性的新兴理念和工具。
F1000Res. 2019 May 29;8. doi: 10.12688/f1000research.17161.1. eCollection 2019.
9
Neuronal activity in the primate premotor, supplementary, and precentral motor cortex during visually guided and internally determined sequential movements.在视觉引导和内部决定的连续运动过程中,灵长类动物运动前区、辅助运动区和中央前运动皮层的神经元活动。
J Neurophysiol. 1991 Sep;66(3):705-18. doi: 10.1152/jn.1991.66.3.705.
10
Neural population dynamics in human motor cortex during movements in people with ALS.肌萎缩侧索硬化症患者运动过程中人类运动皮层的神经群体动力学。
Elife. 2015 Jun 23;4:e07436. doi: 10.7554/eLife.07436.

引用本文的文献

1
Parkinson's Disease Modeling Using Directly Converted 3D Induced Dopaminergic Neuron Organoids and Assembloids.使用直接转化的3D诱导多巴胺能神经元类器官和组装体建立帕金森病模型
Adv Sci (Weinh). 2025 Apr;12(14):e2412548. doi: 10.1002/advs.202412548. Epub 2025 Feb 18.
2
Assembling a Coculture System to Prepare Highly Pure Induced Pluripotent Stem Cell-Derived Neurons at Late Maturation Stages.组装共培养体系以制备高度纯的诱导多能干细胞衍生的晚期成熟神经元。
eNeuro. 2024 Jul 30;11(7). doi: 10.1523/ENEURO.0165-24.2024. Print 2024 Jul.
3
RANBP17 Overexpression Restores Nucleocytoplasmic Transport and Ameliorates Neurodevelopment in Induced DYT1 Dystonia Motor Neurons.

本文引用的文献

1
Disease Modeling with Human Neurons Reveals LMNB1 Dysregulation Underlying DYT1 Dystonia.利用人类神经元进行疾病建模揭示了 DYT1 肌张力障碍中 LMNB1 失调的机制。
J Neurosci. 2021 Mar 3;41(9):2024-2038. doi: 10.1523/JNEUROSCI.2507-20.2020. Epub 2021 Jan 19.
2
Generation and optimization of highly pure motor neurons from human induced pluripotent stem cells via lentiviral delivery of transcription factors.通过慢病毒传递转录因子,从人诱导多能干细胞中生成和优化高度纯的运动神经元。
Am J Physiol Cell Physiol. 2020 Oct 1;319(4):C771-C780. doi: 10.1152/ajpcell.00279.2020. Epub 2020 Aug 12.
3
Differential Influence of Sample Sex and Neuronal Maturation on mRNA and Protein Transport in Induced Human Neurons.
RANBP17 过表达恢复核质转运并改善诱导性 DYT1 肌张力障碍运动神经元的神经发育。
J Neurosci. 2024 Apr 10;44(15):e1728232024. doi: 10.1523/JNEUROSCI.1728-23.2024.
4
DYT- dystonia: an update on pathogenesis and treatment.DYT - 肌张力障碍:发病机制与治疗的最新进展
Front Neurosci. 2023 Aug 10;17:1216929. doi: 10.3389/fnins.2023.1216929. eCollection 2023.
5
Modeling Movement Disorders via Generation of hiPSC-Derived Motor Neurons.通过生成 hiPSC 衍生的运动神经元来模拟运动障碍。
Cells. 2022 Nov 27;11(23):3796. doi: 10.3390/cells11233796.
6
Protocol to image and quantify nucleocytoplasmic transport in cultured cells using fluorescent hybridization and a dual reporter system.使用荧光杂交和双报告基因系统在培养细胞中成像和定量分析核质转运的方案。
STAR Protoc. 2022 Nov 3;3(4):101813. doi: 10.1016/j.xpro.2022.101813. eCollection 2022 Dec 16.
7
Generation of highly pure motor neurons from human induced pluripotent stem cells.从人诱导多能干细胞中生成高纯度运动神经元。
STAR Protoc. 2022 Mar 10;3(1):101223. doi: 10.1016/j.xpro.2022.101223. eCollection 2022 Mar 18.
8
Novel insights into the pathogenesis of DYT1 dystonia from induced patient-derived neurons.来自诱导性患者来源神经元对DYT1肌张力障碍发病机制的新见解。
Neural Regen Res. 2022 Mar;17(3):561-562. doi: 10.4103/1673-5374.320978.
9
Nucleocytoplasmic Transport: Regulatory Mechanisms and the Implications in Neurodegeneration.核质转运:调控机制及其在神经退行性疾病中的意义。
Int J Mol Sci. 2021 Apr 17;22(8):4165. doi: 10.3390/ijms22084165.
样本性别和神经元成熟对诱导人神经元中mRNA和蛋白质运输的差异影响
Front Mol Neurosci. 2020 Apr 3;13:46. doi: 10.3389/fnmol.2020.00046. eCollection 2020.
4
Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models.神经元-神经胶质相互作用增加结节性硬化症患者 iPSC 衍生模型中的神经元表型。
Stem Cell Reports. 2019 Jan 8;12(1):42-56. doi: 10.1016/j.stemcr.2018.11.019. Epub 2018 Dec 20.
5
Induced Pluripotent Stem Cells and Their Use in Human Models of Disease and Development.诱导多能干细胞及其在人类疾病和发育模型中的应用。
Physiol Rev. 2019 Jan 1;99(1):79-114. doi: 10.1152/physrev.00039.2017.
6
Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.在 iPSC 衍生的运动神经元中模拟散发性 ALS 可识别出一种潜在的治疗药物。
Nat Med. 2018 Oct;24(10):1579-1589. doi: 10.1038/s41591-018-0140-5. Epub 2018 Aug 20.
7
BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4.BDNF 通过隔离 NFATc4 来激活依赖于 NFI 的神经发育时间程序。
Mol Biol Cell. 2018 Apr 15;29(8):975-987. doi: 10.1091/mbc.E16-08-0595. Epub 2018 Mar 30.
8
Direct Reprogramming Rather than iPSC-Based Reprogramming Maintains Aging Hallmarks in Human Motor Neurons.直接重编程而非基于诱导多能干细胞的重编程会维持人类运动神经元的衰老特征。
Front Mol Neurosci. 2017 Nov 2;10:359. doi: 10.3389/fnmol.2017.00359. eCollection 2017.
9
Report of the International Stem Cell Banking Initiative Workshop Activity: Current Hurdles and Progress in Seed-Stock Banking of Human Pluripotent Stem Cells.国际干细胞库倡议研讨会活动报告:人类多能干细胞种子库存储的当前障碍和进展。
Stem Cells Transl Med. 2017 Nov;6(11):1956-1962. doi: 10.1002/sctm.17-0144. Epub 2017 Oct 24.
10
Modeling ALS with motor neurons derived from human induced pluripotent stem cells.利用源自人类诱导多能干细胞的运动神经元对肌萎缩侧索硬化症进行建模。
Nat Neurosci. 2016 Apr;19(4):542-53. doi: 10.1038/nn.4273.