Graduate Programs in Human Nutrition, Oregon Health & Science University, Portland, OR, USA.
Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
J Perinatol. 2021 May;41(5):1007-1013. doi: 10.1038/s41372-021-00922-0. Epub 2021 Jan 28.
Increased infant birth weight and adiposity are associated with an altered risk of adult chronic diseases. The objective was to investigate the association between maternal dietary fat intake during pregnancy and newborn adiposity.
The study included 79 singleton pregnancies. Associations between maternal dietary fat intake during each trimester and infant adiposity at birth were assessed.
Average total grams of maternal total dietary fat and unsaturated fat intake during pregnancy correlated with infant percent body fat after adjusting for potential confounding variables (r = 0.23, p = 0.045; r = 0.24, p = 0.037). Maternal average daily intake of total fat, saturated fat, and unsaturated fat during the second trimester of pregnancy were each associated with infant percent body fat (r = 0.25, p = 0.029; r = 0.23, p = 0.046; r = 0.25, p = 0.031; respectively).
The second trimester of pregnancy is a key time period for fetal adipose tissue metabolic programming and therefore a target for nutritional intervention.
婴儿出生体重和肥胖增加与成人慢性病风险改变有关。本研究旨在调查孕妇妊娠期间的饮食脂肪摄入量与新生儿肥胖之间的关系。
本研究纳入了 79 例单胎妊娠。评估了每个孕期的母体饮食脂肪摄入量与新生儿出生时肥胖的相关性。
在调整潜在混杂变量后，孕妇妊娠期间总膳食脂肪和不饱和脂肪的平均总克数与婴儿的体脂百分比相关（r=0.23，p=0.045；r=0.24，p=0.037）。妊娠中期，母体总脂肪、饱和脂肪和不饱和脂肪的平均日摄入量均与婴儿的体脂百分比相关（r=0.25，p=0.029；r=0.23，p=0.046；r=0.25，p=0.031；分别）。
妊娠中期是胎儿脂肪组织代谢编程的关键时期，因此也是营养干预的目标时期。
