Takeda S, Matsuzawa T, Matsui H
Department of Radiology and Nuclear Medicine, Tohoku University, Sendai, Japan.
J Am Geriatr Soc. 1988 Apr;36(4):293-7. doi: 10.1111/j.1532-5415.1988.tb02353.x.
Using the xenon-133 inhalation method, we studied the age-related decline in regional cerebral blood flow, calculated as the initial slope index (ISI), in neurologically normal subjects without any risk factors for cerebral arteriosclerosis (154 men and 123 women), ranging in age from 19 to 88 years. The decline in the ISI was rapid in younger age groups and gradual in older age groups. The ISI was higher in women than in men older than 40 years. Using computed tomography, we studied the age-related decline in brain volume index (BVI; 100% X brain volume/cranial cavity volume) in neurologically normal subjects without any risk factors for cerebral arteriosclerosis (92 men and 49 women), ranging in age from 37 to 86 years. The decline in the BVI was gradual in younger age groups and rapid in older age groups. The BVI was higher in women than in men older than 60 years.
我们采用氙-133吸入法，对年龄在19至88岁之间、无任何脑动脉硬化危险因素的神经功能正常受试者（154名男性和123名女性）进行研究，计算局部脑血流量的年龄相关下降情况，以初始斜率指数（ISI）表示。ISI在较年轻年龄组下降迅速，在较年长年龄组下降缓慢。40岁以上女性的ISI高于男性。我们使用计算机断层扫描，对年龄在37至86岁之间、无任何脑动脉硬化危险因素的神经功能正常受试者（92名男性和49名女性）进行研究，计算脑容量指数（BVI；100%×脑容量/颅腔容量）的年龄相关下降情况。BVI在较年轻年龄组下降缓慢，在较年长年龄组下降迅速。60岁以上女性的BVI高于男性。
