钙网织蛋白暴露的颠覆作为免疫逃避的一种策略。
Subversion of calreticulin exposure as a strategy of immune escape.
机构信息
Equipe Labellisée par la Ligue Contre le Cancer, Université de Paris, Sorbonne Université, Inserm U1138, Centre de Recherche des Cordeliers, Paris, France; Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, Paris, France; Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China; Karolinska Institute, Department of Women's and Children's Health, Karolinska University Hospital, Stockholm, Sweden.
Suzhou Institute for Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China; Faculty of Medicine, Université Paris Saclay, Le Kremlin-Bicêtre, France; Gustave Roussy Comprehensive Cancer Institute, Villejuif, France; INSERM U1015, Villejuif, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 1428 BIOTHERIS, Villejuif, France.
出版信息
Cancer Cell. 2021 Apr 12;39(4):449-451. doi: 10.1016/j.ccell.2021.01.014. Epub 2021 Jan 28.
In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the "eat me" signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.
在本期中，Lin 等人报告称，在恶性细胞中，STC1 可防止“吃我”信号钙网织蛋白的细胞表面暴露，从而避免抗原呈递细胞的吞噬作用。STC1 的过表达加入了一系列机制，肿瘤细胞通过这些机制抑制钙网织蛋白的暴露并逃避免疫监视。
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