Sakakibara S
Department of Perinatology, National Cardio Vascular Center, Osaka.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Jan;40(1):36-42.
The lecithin/sphingomyelin (L/S) ratios in standard solution and amniotic fluid of 64 pregnant women were measured by high performance liquid chromatography (HPLC). The procedure is highly accurate, and the correlation coefficient between the HPLC value and standard solution was 0.984. The regression line was: Y = 0.8X + 0.17 (Y: standard solution X: HPLC values). In 64 pregnant women, 41 cases were delivered within 72 hrs of the amniotic fluid collection. The prediction of respiratory distress syndrome (RDS) was performed with variables of the L/S ratio less than 4.20. 8 of 9 babies (88.9% of sensitivity) who developed RDS and 3 of 3 (100% of sensitivity) other types of respiratory failure due to hydrothorax were predicted by this method. In conclusion, this method is simple, rapid and sensitive for the prediction of respiratory distress syndrome and other respiratory failure.
采用高效液相色谱法（HPLC）测定了64例孕妇标准溶液和羊水的卵磷脂/鞘磷脂（L/S）比值。该方法具有很高的准确性，HPLC值与标准溶液之间的相关系数为0.984。回归线为：Y = 0.8X + 0.17（Y：标准溶液；X：HPLC值）。64例孕妇中，41例在羊水采集后72小时内分娩。以L/S比值小于4.20为变量对呼吸窘迫综合征（RDS）进行预测。该方法预测出9例发生RDS的婴儿中的8例（敏感性为88.9%）以及3例因胸腔积液导致的其他类型呼吸衰竭中的3例（敏感性为100%）。总之，该方法对于预测呼吸窘迫综合征和其他呼吸衰竭简单、快速且灵敏。
