核酸纳米颗粒（NANPs）诱导细胞因子取决于递送载体的类型。
Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier.
机构信息
Nanoscale Science Program, Department of Chemistry, University of North Carolina Charlotte, Charlotte, NC 28223-0001, USA.
Nanotechnology Characterization Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research Sponsored by the National Cancer Institute, Frederick, MD 21702, USA.
出版信息
Molecules. 2021 Jan 27;26(3):652. doi: 10.3390/molecules26030652.
Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these studies have used a single lipid-based carrier to allow for NANPs' intracellular delivery, it is now apparent that the platform for delivery, which has historically been a hurdle for therapeutic nucleic acids, is an additional means to tailoring NANP immunorecognition. Here, the use of dendrimers for the delivery of NANPs is compared to the lipid-based platform and the differences in resulting cytokine induction are presented.
最近对核酸纳米颗粒（NANP）的免疫刺激特性的深入了解表明，形状、大小和组成的变化导致其免疫刺激特性的明显差异。虽然这些研究大多数都使用了单一的基于脂质的载体来实现 NANP 的细胞内递送，但现在显然，作为治疗性核酸的一个历史障碍的递送平台，也是一种可以用来调整 NANP 免疫识别的方法。在这里，将比较树枝状聚合物作为 NANP 递药载体与基于脂质的平台，并介绍了由此产生的细胞因子诱导的差异。
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