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两种 品种根提取物：脂质成分和对不同细胞系的生物学效应：初步结果。

Root Extracts of Two Cultivars of Species: Lipid Composition and Biological Effects on Different Cell Lines: Preliminary Results.

机构信息

Department of Pharmacy and Biotechnology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy.

National Institute of Biostructures and Biosystems, Via delle Medaglie D'oro 305, 00136 Roma, Italy.

出版信息

Molecules. 2021 Jan 27;26(3):655. doi: 10.3390/molecules26030655.

DOI:10.3390/molecules26030655
PMID:33513825
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7865396/
Abstract

The roots of two cultivars of , namely "Rubra Plena" and "Pink Hawaiian Coral", have been extracted with chloroform. The composition of the lipid fraction, analyzed by GC-MS technique, revealed the absence of paeonol and the presence of phenol, benzoic acid, fatty acid-and some sterol-derivatives. The chloroformic extracts have been tested on normal and several cancer cell lines but showed antiproliferative activity only on the ovarian carcinoma and the osteosarcoma. The biological activity of extracts was investigated mainly by confocal microscopy, flow cytometry and quantum phase imaging. The results indicated that the root extracts induced a hyperpolarization of mitochondria and an increase in reactive oxygen species levels, without inducing cell death. These effects are associated to an increased doubling time and a retarded confluence.

摘要

已用氯仿提取了两个品种的根，即“Rubra Plena”和“Pink Hawaiian Coral”。通过 GC-MS 技术分析脂质部分的组成，发现不存在丹皮酚，而存在苯酚、苯甲酸、脂肪酸和一些甾体衍生物。氯仿提取物已在正常细胞系和几种癌细胞系上进行了测试，但仅对卵巢癌和骨肉瘤显示出抗增殖活性。提取物的生物活性主要通过共聚焦显微镜、流式细胞术和量子相位成像进行了研究。结果表明，根提取物诱导线粒体超极化和活性氧水平增加，但不会诱导细胞死亡。这些作用与倍增时间增加和汇合延迟有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/66a4e91c00af/molecules-26-00655-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/d760195b49fb/molecules-26-00655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/3f3854032799/molecules-26-00655-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/9a9341f1091d/molecules-26-00655-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/462e4750ca75/molecules-26-00655-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/5c4b49c09c9c/molecules-26-00655-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/66a4e91c00af/molecules-26-00655-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/d760195b49fb/molecules-26-00655-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/3f3854032799/molecules-26-00655-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/9a9341f1091d/molecules-26-00655-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/462e4750ca75/molecules-26-00655-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/5c4b49c09c9c/molecules-26-00655-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a155/7865396/66a4e91c00af/molecules-26-00655-g006.jpg

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