干酪乳杆菌对酒精性肝损伤患者脂代谢及肠道微生态的影响。
Effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury.
机构信息
Department of Human Nutrition, College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, China.
Department of Clinical Nutrition, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Shandong, 264000, China.
出版信息
Eur J Clin Nutr. 2021 Aug;75(8):1227-1236. doi: 10.1038/s41430-020-00852-8. Epub 2021 Jan 29.
BACKGROUND
The present study aims to investigate the effect of Lactobacillus casei on lipid metabolism and intestinal microflora in patients with alcoholic liver injury.
METHODS
In a double-blind randomized controlled trial, 158 recruited alcoholic liver injury patients were randomized to three treatments for 60 days: low-dose group (LP, n = 58, 100 ml of Lactobacillus casei strain Shirota (LcS)), high-dose group (HP, n = 54, 200 ml of LcS), and positive control group (PC, n = 46, 100 ml of special drinks without active Lactobacillus casei). Another group of 20 healthy people was served as normal control group (NC).
RESULTS
The serum levels of TG and LDLC in the HP group were significantly decreased by 26.56% and 23.83%, respectively than those in the PC group (P < 0.05). After supplementation of Lactobacillus casei, there was a significant increase in the amount of Lactobacillus and Bifidobacterium when compared with the PC group (P < 0.05).
CONCLUSIONS
Supplementation of Lactobacillus casei can improve lipid metabolism and regulate intestinal flora disorders in patients with alcoholic liver injury.
背景
本研究旨在探讨干酪乳杆菌对酒精性肝损伤患者脂代谢和肠道菌群的影响。
方法
采用双盲随机对照试验，将 158 例酒精性肝损伤患者随机分为 3 组，分别接受 60 天的治疗：低剂量组（LP，n=58，100ml 干酪乳杆菌 Shirota 株（LcS））、高剂量组（HP，n=54，200ml LcS）和阳性对照组（PC，n=46，100ml 无活性干酪乳杆菌的特殊饮料）。另设 20 名健康人作为正常对照组（NC）。
结果
与 PC 组相比，HP 组的血清 TG 和 LDLC 水平分别显著降低了 26.56%和 23.83%（P<0.05）。补充干酪乳杆菌后，与 PC 组相比，乳杆菌和双歧杆菌的数量明显增加（P<0.05）。
结论
补充干酪乳杆菌可改善酒精性肝损伤患者的脂代谢，调节肠道菌群紊乱。
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