Division of Hospital Pharmacy Science, Keio University Faculty of Pharmacy, Japan.
Division of Hospital Pharmacy Science, Keio University Faculty of Pharmacy, Japan; Department of Pharmacy, Keio University Hospital, Japan.
Int J Pharm. 2021 Mar 1;596:120249. doi: 10.1016/j.ijpharm.2021.120249. Epub 2021 Jan 28.
In the treatment of asthma and chronic obstructive pulmonary disease, using a lever aid to improve drug delivery from an inhaler is recommended for patients with poor muscle strength. However, no studies have investigated the effect on hand strength of using a lever aid. Here, we measured hand strength before and after operating a lever aid and tried to predict the required strength. We compared the pinch force required to activate a pressurized metered dose inhaler (pMDI) and a dry powder inhaler as well as the rotational torque required to activate a soft mist inhaler (SMI) before and after attaching a lever aid. We then assessed the correlation between the theoretical and measured pinch force after fitting the lever aid. Use of the lever aid significantly reduced the pinch force required for pMDI operation from 26.13-48.74 N to 4.90-16.87 N. In contrast, using a lever aid significantly reduced the force needed to rotate SMI, although the rotational torque required to operate did not change. There was a significant positive correlation between the theoretical and measured pinch forces required to activate a pMDI fitted with a lever aid. Using a lever aid will increase the number of patients who can use this device.
在哮喘和慢性阻塞性肺疾病的治疗中，建议肌肉力量较弱的患者使用杠杆辅助器来改善吸入器的药物输送效果。然而，目前还没有研究调查使用杠杆辅助器对手部力量的影响。在这里，我们测量了使用杠杆辅助器前后的手部力量，并尝试预测所需的力量。我们比较了在安装杠杆辅助器前后，激活压力定量吸入器（pMDI）和干粉吸入器所需的捏力，以及激活软雾吸入器（SMI）所需的旋转扭矩。然后，我们评估了安装杠杆辅助器后理论和测量捏力之间的相关性。使用杠杆辅助器可将操作 pMDI 所需的捏力从 26.13-48.74N 显著降低至 4.90-16.87N。相比之下，使用杠杆辅助器可显著降低操作 SMI 所需的力，尽管操作所需的旋转扭矩并未改变。装有杠杆辅助器的 pMDI 激活所需的理论和测量捏力之间存在显著的正相关关系。使用杠杆辅助器将增加能够使用该设备的患者数量。
