Mapondela Kassim Babu, Dey Roopam, Levin Michael
Division of Paediatric Allergology, Department of Paediatrics and Adolescent Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Division of Biomedical Engineering, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
J Allergy Clin Immunol Glob. 2023 Jun 12;2(3):100126. doi: 10.1016/j.jacig.2023.100126. eCollection 2023 Aug.
Activating pressurized metered dose inhalers (pMDIs) is often challenging for children. The Easy Squeezy (ES) is a novel sleeve attachment device that reduces activation force by 3 times. Although users have favored using the ES over using a pMDI alone, the clinical impact of the ES remains unknown. The aim of this study was to compare lung function and quality of life between ES users and users of a pMDI alone.
Our aim was to measure and compare lung function of asthmatic children after they used the ES and pMDI alone.
In this crossover study we recruited 65 asthmatic children between the ages of 5 and 12 years. The participants were randomized into 2 groups. One of the groups used the ES for 6 weeks whereas the other group used a pMDI. After 6 weeks the participants crossed over to the other group. Lung function test parameters were measured after randomization and after each 6 weeks of device use. Quality of life (measured by the Patient Asthma Quality of Life Questionnaire [PAQLQ]) and Childhood Asthma Control Test were measured after each period of device use.
There was no significant difference in the baseline lung function between the groups. The ES group had a significantly lower percentage difference between prebronchodilator and postbronchodilator FEV values. Although no significant differences were observed in PAQLQ scores between the groups, more patients in the ES group had improvement of their PAQLQ score than did patients in the group using a pMDI alone. Total Childhood Asthma Control Test scores were significantly higher for the ES group.
The ES device may allow users' asthma to be better controlled than by using a pMDI alone.
对于儿童而言，激活压力定量吸入器（pMDIs）通常具有挑战性。易挤压（ES）是一种新型的套筒式附加装置，可将激活力降低3倍。尽管与单独使用pMDI相比，使用者更倾向于使用ES，但ES的临床影响仍不明确。本研究的目的是比较ES使用者和单独使用pMDI的使用者之间的肺功能和生活质量。
我们的目的是测量和比较哮喘儿童单独使用ES和pMDI后的肺功能。
在这项交叉研究中，我们招募了65名年龄在5至12岁之间的哮喘儿童。参与者被随机分为两组。其中一组使用ES 6周，而另一组使用pMDI。6周后，参与者交叉到另一组。在随机分组后以及每次使用装置6周后测量肺功能测试参数。在每次使用装置期间后测量生活质量（通过患者哮喘生活质量问卷[PAQLQ]进行测量）和儿童哮喘控制测试。
两组之间的基线肺功能无显著差异。ES组支气管扩张剂使用前和使用后FEV值的百分比差异显著更低。尽管两组之间在PAQLQ评分上未观察到显著差异，但ES组中PAQLQ评分改善的患者比单独使用pMDI组的患者更多。ES组的儿童哮喘控制测试总评分显著更高。
与单独使用pMDI相比，ES装置可能使使用者的哮喘得到更好的控制。
