Sistema BioTech, LLC, 34 bldg. 11, 5th Floor, Premises I, Room 13, 1st Kuryanovskaya st., 109235, Moscow, Russian Federation; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 32 Vavilova st., 119991, Moscow, Russian Federation.
Laboratory of Structure and Functions of Muscle Proteins, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 3 Institutskaya st., 142290, Pushchino, Moscow Region, Russian Federation; Laboratory of Cell Mechanisms of Memory Pathology, Institute of Cell Biophysics, Federal Research Center Pushchino Research Center of Biological Studies, Russian Academy of Science, Pushchino, Moscow Region, Russian Federation.
Ageing Res Rev. 2021 May;67:101262. doi: 10.1016/j.arr.2021.101262. Epub 2021 Jan 28.
Hydrogen sulfide (HS) is one of the biologically active gases (gasotransmitters), which plays an important role in various physiological processes and aging. Its production in the course of methionine and cysteine catabolism and its degradation are finely balanced, and impairment of HS homeostasis is associated with various pathologies. Despite the strong geroprotective action of exogenous HS in C. elegans, there are controversial effects of hydrogen sulfide and its donors on longevity in other models, as well as on stress resistance, age-related pathologies and aging processes, including regulation of senescence-associated secretory phenotype (SASP) and senescent cell anti-apoptotic pathways (SCAPs). Here we discuss that the translation potential of HS as a geroprotective compound is influenced by a multiplicity of its molecular targets, pleiotropic biological effects, and the overlapping ranges of toxic and beneficial doses. We also consider the challenges of the targeted delivery of HS at the required dose. Along with this, the complexity of determining the natural levels of HS in animal and human organs and their ambiguous correlations with longevity are reviewed.
硫化氢（HS）是一种具有生物活性的气体（气体递质），在各种生理过程和衰老中起着重要作用。其在蛋氨酸和半胱氨酸分解代谢过程中的产生及其降解被精细地平衡，HS 动态平衡的破坏与各种病理有关。尽管外源性 HS 在秀丽隐杆线虫中具有强烈的抗衰老作用，但在其他模型中，以及在应激抵抗、与年龄相关的病理和衰老过程中，包括对衰老相关分泌表型（SASP）和衰老细胞抗凋亡途径（SCAPs）的调节，氢硫 化物及其供体对长寿的影响存在争议。在这里，我们讨论了 HS 作为一种抗衰老化合物的转化潜力受到其多种分子靶点、多效性的生物学效应以及毒性和有益剂量的重叠范围的影响。我们还考虑了在所需剂量下靶向输送 HS 的挑战。与此同时，还审查了在动物和人体器官中确定 HS 自然水平的复杂性及其与长寿的模糊相关性。
