Amsterdam UMC, Vrije Universiteit, Department of Neurosurgery, Cancer Center, Amsterdam, Netherlands.
Amsterdam UMC, Vrije Universiteit, Department of Medical Psychology, Neuroscience Campus, Amsterdam, Netherlands.
Neurosurgery. 2021 Mar 15;88(4):720-732. doi: 10.1093/neuros/nyaa365.
Functional outcome following glioma surgery is defined as how the patient functions or feels. Functional outcome is a coprimary end point of surgery in patients with diffuse glioma, together with oncological outcome. In this review, we structure the functional outcome measurements following glioma surgery as reported in the last 5 yr. We review various perspectives on functional outcome of glioma surgery with available measures, and offer suggestions for their use. From the recent neurosurgical literature, 160 publications were retrieved fulfilling the selection criteria. In these publications, neurological outcomes were reported most often, followed by activities of daily living, seizure outcomes, neurocognitive outcomes, and health-related quality of life or well-being. In more than a quarter of these publications functional outcome was not reported. A minimum essential consensus set of functional outcome measurements would benefit comparison across neurosurgical reports. The consensus set should be based on a combination of clinician- and patient-reported outcomes, assessed at a predefined time before and after surgery. The selected measurements should have psychometric properties supporting the intended use including validity-related evidence, reliability, and sensitivity to detect meaningful change with minimal burden to ensure compliance. We circulate a short survey as a start towards reporting guidelines. Many questions remain to better understand, report, and improve functional outcome following glioma surgery.
神经胶质瘤手术后的功能结果定义为患者的功能或感觉。功能结果是弥漫性神经胶质瘤患者手术的主要终点之一，与肿瘤学结果一起。在这篇综述中，我们将过去 5 年报道的神经胶质瘤手术后的功能结果测量方法进行了分类。我们回顾了神经胶质瘤手术功能结果的各种观点和可用的测量方法，并提出了使用这些方法的建议。从最近的神经外科文献中，检索到 160 篇符合选择标准的出版物。在这些出版物中，最常报告的是神经功能结局，其次是日常生活活动、癫痫结局、神经认知结局以及健康相关的生活质量或幸福感。在超过四分之一的出版物中没有报告功能结果。一个最小的基本共识功能结果测量集将有助于比较神经外科报告。共识集应基于临床医生和患者报告的结果的组合，在手术前后的预定时间进行评估。所选的测量方法应具有支持预期用途的心理测量学特性，包括与有效性相关的证据、可靠性和检测有意义变化的敏感性，同时最小化负担以确保合规性。我们正在进行一项简短的调查，作为报告指南的起点。还有许多问题需要进一步了解、报告和改善神经胶质瘤手术后的功能结果。
