DSM Nutritional Products AG, Animal Nutrition & Health, Kaiseraugst, Switzerland.
DSM Nutritional Products, Research Center for Animal Nutrition & Health, Village-Neuf, France.
Poult Sci. 2021 Mar;100(3):100800. doi: 10.1016/j.psj.2020.10.054. Epub 2020 Nov 5.
A meta-analysis of 19 floor-pen trials (579 replicate pen observations) in diverse geographies, basal diets, seasons, and medication programs was carried out to evaluate the effects of 2 precision glycan microbiome metabolic modulators (MMM1 and MMM2) on the performance of broiler chickens. In each trial, negative-control (NC) diets were compared with either MMM1 (14 trials) or MMM2 (8 trials), supplemented at an intended dose of 500 g/MT from hatch to 31 to 42 d. A dose response of MMM2 was evaluated in 8 trials at doses of 100, 250, 500, and 1,000 g/MT, not all present in each trial. Linear mixed-effect models were constructed for the final BW, cumulative feed intake, feed conversion ratio (FCR) corrected by mortality and BW (cFCR), and mortality, with Treatment as the fixed effect, nested random effects of Trial and Block, and adjustments for heterogeneity of variances. A significance level of P < 0.05 was used. In one of the studies, cecal content samples were collected at 42 d for analysis of microbiome gene abundance. Microbiome metabolic modulator 2 exhibited a reduction of the cFCR of 0.06 g feed/g BW gain compared with the NC and 0.03 g feed/g BW gain compared with MMM1, whereas MMM1 reduced the cFCR by 0.03 g feed/g BW gain compared with NC. Both MMM1 and MMM2 increased the final BW compared with the NC by 43 and 48 g/bird, respectively, with no difference among them. Compared with NC, feed intake was increased by MMM1 (+51 g/bird) and reduced by MMM2 (-74 g/bird). A one-directional dose response of the MMM2 ingredient was observed for the final BW (increasing) and cFCR (decreasing), whereas the feed intake response reached a minimum at 500 g/MT. The metagenomic analysis confirmed an increase in the abundance of genes belonging to the acrylate pathway, which is involved in propionate production, as well as arginine-N-succinyl transferase which is involved in the catabolism of arginine, in response to MMM2. Differential glycan structures of the MMM had an impact on the size and consistency of performance effects in broilers.
进行了一项荟萃分析，共纳入 19 项笼养试验（579 个重复笼位观察），这些试验分布在不同地理位置、基础饲粮、季节和药物方案中，旨在评估 2 种精准聚糖微生物组代谢调节剂（MMM1 和 MMM2）对肉鸡生产性能的影响。在每项试验中，将阴性对照（NC）饲粮与 MMM1（14 项试验）或 MMM2（8 项试验）进行比较，从孵化到 31-42 日龄时，按 500 g/MT 的预期剂量添加。在 8 项试验中评估了 MMM2 的剂量反应，剂量分别为 100、250、500 和 1000 g/MT，但并非所有试验都包含所有剂量。最终体重、累计采食量、死亡率校正的饲料转化率（cFCR）和死亡率采用线性混合效应模型进行分析，处理为固定效应，嵌套试验和区组随机效应，并用方差异质性调整。采用 P < 0.05 作为显著性水平。在其中一项研究中，在 42 日龄时收集盲肠内容物样本，用于分析微生物组基因丰度。与 NC 相比，MMM2 使 cFCR 降低了 0.06 g 饲料/g 体重增加，与 MMM1 相比降低了 0.03 g 饲料/g 体重增加，而 MMM1 使 cFCR 降低了 0.03 g 饲料/g 体重增加与 NC 相比。与 NC 相比，MMM1 和 MMM2 分别使终体重增加了 43 和 48 g/只，两者之间没有差异。与 NC 相比，MMM1 使采食量增加了 51 g/只，而 MMM2 使采食量减少了 74 g/只。MMM2 成分的终重（增加）和 cFCR（降低）呈单向剂量反应，而采食量反应在 500 g/MT 时达到最小值。宏基因组分析证实，与 MMM2 反应的丙烯酸盐途径相关基因的丰度增加，而参与脯氨酸生产的丙氨酸-N-琥珀酰转移酶的基因丰度增加，而精氨酸的分解代谢也参与其中。MMM 的不同聚糖结构对肉鸡生产性能的大小和一致性有影响。
